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Infectious Disease Antibodies

Infectious diseases are diseases caused by organisms such as bacteria, viruses, fungi, or parasites. These microorganisms can colonize in and out of our bodies and can cause disease. Some of these diseases are communicable, meaning they can be passed from one person to another. Other infectious diseases can be transmitted via bites from other vectors like insects or animals. Infectious diseases can even be ingested through contaminated food or water or other environmental factors. Typically infectious diseases are labeled as contagious although certain types of infectious disease are transmitted by specialized routes of action like vector or sexual transmission. Healthy individuals, without compromised immune systems, are typically at a lower risk of becoming infected by ubiquitous microorganisms. A person’s hygiene, such as hand washing, is also a very effective defense against the spread of infectious disease. Examples of infectious diseases include AIDS (acquired immunodeficiency syndrome), anthrax, gonorrhea, hepatitis, herpes, the flu, and tinea pedis (athlete’s foot). Treatment, of course, will vary depending on the organism causing the infection. Infectious disease antibodies are useful in research and medicine specifically for the purpose of vaccine development. Immunizations or vaccines against infectious diseases are useful in eliciting an immune response from an organism. Antibodies are produced against a dead or weakened sample of an infectious agent and remain in the bloodstream to attack any future invaders. The chance of symptomatic reactions to a vaccine is limited in comparison to a full blown attack of the microorganism. The antibodies produced are then available to prevent any attacks of that specific antigen in the future. Vaccines are available to protect people from diseases like polio, measles, human papillomavirus, pertussis, meningitis C, and diphtheria. Other animals can get vaccinated for infectious disease as well. Dogs can be vaccinated for distemper, parvovirus, bordetella, rabies, and rattlesnake bites. Cats can be vaccinated for autoimmune diseases feline leukemia and feline infectious virus.

The notch 2 protein is a receptor on the membrane of cells and binds to ligands and anti- notch 2 antibodies. These proteins regulate the fate of the cell by influencing processes including differentiation, proliferation, and apoptosis (specifically of osteoclasts or bone cells). Defects in NOTCH2 cause Alagille syndrome type 2 and Hajdu-Cheney syndrome (HJCYS). Alagille syndrome is a form of arteriohepatic dysplasia which involves multisystem defects characterized by chronic cholestasis due to paucity of intrahepatic bile ducts, peripheral pulmonary artery stenosis, and dysplastic kidneys. Alagille syndrome is inherited by an autosomal dominant fashion. HJCYS is a skeletal disorder. Affected individuals have facial defects, osteoporosis, acro-osteolysis, and periodontal disease. The anti-FLVCR antibody binds against FLVCR1 protein which is a heme transporter that exports cytoplasmic heme. The FLVCR target also functions to export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. FLVCR protein is expressed on the cell membrane in all hematopoietic tissues including peripheral blood lymphocytes and to some extent in the pancreas and kidneys. Defects in FLVCR1 are the cause of posterior column ataxia with retinitis pigmentosa (PCARP). Posterior column ataxia with retinitis pigmentosa causes affected individuals to suffer from night blindness and peripheral vision abnormalities as children or infants and eventually lose their site entirely. Sensory ataxia, or loss of coordination, is caused by degeneration of the posterior columns of the spinal cord.

Product Number Title Applications Host Clonality
AC21-0021-01 Anti-DDB1 Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0021-02 Anti-DDB1 Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0021-03 Anti-DDB1 Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0021-04 Anti-DDB1 Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal
AC21-0021-05 Anti-DDB1 Antibody (APC-Cy7) ELISA, WB Goat Polyclonal
AC21-0021-06 Anti-DDB1 Antibody (Avidin) ELISA, WB Goat Polyclonal
AC21-0021-07 Anti-DDB1 Antibody (Biotin) ELISA, WB Goat Polyclonal
AC21-0021-08 Anti-DDB1 Antibody (BPE) ELISA, WB Goat Polyclonal
AC21-0021-09 Anti-DDB1 Antibody (Cy3) ELISA, WB Goat Polyclonal
AC21-0021-10 Anti-DDB1 Antibody (Cy5) ELISA, WB Goat Polyclonal
AC21-0021-11 Anti-DDB1 Antibody (Cy5.5) ELISA, WB Goat Polyclonal
AC21-0021-12 Anti-DDB1 Antibody (FITC) ELISA, WB Goat Polyclonal