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Immunology Antibodies

Immunology is the study of the immune system and its functions. This branch of biomedical science deals with the physiological aspects of the immune system including how it keeps an organism healthy and/or disorders or dysfunctions of the immune system which cause disease. The immune system consists of many cells, tissues, and organs that can function together in order to protect the body against foreign attacks from invaders like bacteria, viruses, and other organisms such as parasites. When the immune system fails to function or malfunctions, problems arise. Autoimmune disorders, organ transplant rejection, and immunodeficiency are common types of immune system dysfunction. The immune system can function in either specific, adaptive ways or in innate or non-specific ways. Innate, or non-specific immune functions, include first line of defense barriers which include the skin, mucous membranes, and bodily secretions like saliva, ears, and sweat. Specific immune responses are antigen-dependent and involve the body's ability to produce immunology antibodies in response to bodily invaders. An antigen is any substance that elicits an immune response. Antibodies, or immunoglobulins, are protein molecules produced in response to an antigen. An organism can produce multiple antibodies in response to a single antigen. This is due to the complicated protein structure of the antigen with many sites upon which an antibody may bind. The antibody producing immune response is adaptive meaning the cells of future generations will inherit the genes encoding for those antibodies. In essence, the immune system can react with increasingly effective defense mechanisms with each encounter against the same microbe or foreign antigen.

Anti-BLNK antibody binds against the antigen target BLNK. BLNK functions as a linker protein that connects phosphate enzymes (kinases) with B-cell receptors. BLNK also plays an integral role in BCR (B-cell receptor) induced B-cell apoptosis. BLNK is located in the cytoplasm and cell membrane and expressed in the highest levels in the spleen with lower concentrations in the liver, pancreas, small intestines, and colon. Defects in BLNK cause agammaglobulinemia type 4. Agammaglobulinemia affects the body's ability to fight infections by blocking the body's ability to generate mature B cells. Affected individuals lack effective levels of antibodies in their bloodstream and often times develop serious and fatal infections. Anti-CD20 antibody binds against CD20. CD 20 is involved in the regulation of B-cell activation and proliferation. B lymphocyte antigen CD20 is expressed on B-cell membranes. Defects in the gene that encodes for CD20 are the cause of immunodeficiency common variable type 5. Common variable immune deficiency is characterized by humoral immune deficiency which results in an individual's susceptibility to infections and decreased response to vaccinations. Common variable immune deficiency has better outcomes than agammaglobulinemia wherein affected individuals often have amounts of circulating B cells in the normal-low range and suffer from frequent bacterial infections.

 
Product Number Title Applications Host Clonality
AC16-0033 Anti-CD4 Antibody ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0034 Anti-IL12A Antibody ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0035 Anti-CD40 Antibody ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (FGK45)
AC16-0041 Anti-Visfatin Antibody ELISA, WB, IHC(F), IHC(P) Rat Monoclonal (14A5)
AC16-0048 Anti-TNF Receptor I Antibody ELISA, WB, IHC(P), FC Rabbit Polyclonal
AC16-0058 Anti-F4/80 Antibody ELISA, WB, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (BM8)
AC16-0059 Anti-TNF Receptor I Antibody ELISA, IHC(F), ICC, IF, FC Mouse Monoclonal (htr9)
AC16-0060 Anti-TNF Receptor I Antibody WB, IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (utr1)
AC16-0033-01 Anti-CD4 Antibody (AMCA) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-02 Anti-CD4 Antibody (AP) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-03 Anti-CD4 Antibody (APC) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-04 Anti-CD4 Antibody (APC-Cy5.5) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
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  1. Adaptive Immunity (3350)
  2. Immune System Diseases (1443)
  3. Immunoglobulins (867)
  4. Innate Immunity (4330)
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  14. WB (7360)
Conjugate
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  2. Alexa FluorÔö¼┬½ 488 Fab fragment (1)
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Clonality
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  2. Monoclonal (1-13M1) (23)
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  5. Monoclonal (100/D5+124) (23)
  6. Monoclonal (104D2) (6)
  7. Monoclonal (14) (23)
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  9. Monoclonal (14A5) (23)
  10. Monoclonal (15.2) (23)
  11. Monoclonal (16-10A1) (1)
  12. Monoclonal (1696) (2)
  13. Monoclonal (17D9) (23)
  14. Monoclonal (1aG4/C5) (1)
  15. Monoclonal (1D11) (4)
  16. Monoclonal (1D3) (2)
  17. Monoclonal (1E7.2) (3)
  18. Monoclonal (1H4) (7)
  19. Monoclonal (24) (23)
  20. Monoclonal (28) (23)
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  22. Monoclonal (2B11 + PD7/26) (23)
  23. Monoclonal (2H11) (23)
  24. Monoclonal (2H7) (9)
  25. Monoclonal (31A3) (23)
  26. Monoclonal (341) (2)
  27. Monoclonal (37.51) (1)
  28. Monoclonal (38) (23)
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  31. Monoclonal (3G3) (4)
  32. Monoclonal (3G8) (11)
  33. Monoclonal (45M1) (23)
  34. Monoclonal (4A11) (2)
  35. Monoclonal (4C2) (4)
  36. Monoclonal (4C6-H8) (23)
  37. Monoclonal (4G7 ) (10)
  38. Monoclonal (4G7) (1)
  39. Monoclonal (4H10) (3)
  40. Monoclonal (4H11[APG]) (9)
  41. Monoclonal (4H84) (2)
  42. Monoclonal (53-6.7) (8)
  43. Monoclonal (581) (7)
  44. Monoclonal (58M1) (23)
  45. Monoclonal (5A6G7) (4)
  46. Monoclonal (5E10) (4)
  47. Monoclonal (67) (23)
  48. Monoclonal (7C9) (23)
  49. Monoclonal (87G) (6)
  50. Monoclonal (8F9) (23)
  51. Monoclonal (9-13M1) (23)
  52. Monoclonal (A103 + M2-7C10 + M2-9E3) (23)
  53. Monoclonal (A67-B/E3) (23)
  54. Monoclonal (A8B5) (4)
  55. Monoclonal (A9E4) (23)
  56. Monoclonal (AC2) (23)
  57. Monoclonal (AD3) (1)
  58. Monoclonal (AK4) (4)
  59. Monoclonal (APA1/1) (3)
  60. Monoclonal (B-A8) (1)
  61. Monoclonal (B72.3 + CC49) (23)
  62. Monoclonal (BA5b) (5)
  63. Monoclonal (BB7.1) (25)
  64. Monoclonal (BB7.2) (3)
  65. Monoclonal (BE5) (4)
  66. Monoclonal (Ber-ACT8) (3)
  67. Monoclonal (BM8) (23)
  68. Monoclonal (BRD469) (23)
  69. Monoclonal (BRD494) (23)
  70. Monoclonal (BU15) (6)
  71. Monoclonal (BU20a) (23)
  72. Monoclonal (BU32) (23)
  73. Monoclonal (BU63) (7)
  74. Monoclonal (BV10A4) (2)
  75. Monoclonal (BX006 + 2H12) (23)
  76. Monoclonal (C-J4C4/1) (23)
  77. Monoclonal (C17.8) (23)
  78. Monoclonal (C2) (1)
  79. Monoclonal (C31.3) (23)
  80. Monoclonal (C35) (23)
  81. Monoclonal (C4D204) (23)
  82. Monoclonal (C5) (1)
  83. Monoclonal (C6) (1)
  84. Monoclonal (C68/684) (23)
  85. Monoclonal (C7) (2)
  86. Monoclonal (CB3-1) (3)
  87. Monoclonal (CB30) (1)
  88. Monoclonal (CB38 (NL07)) (4)
  89. Monoclonal (CCP58) (23)
  90. Monoclonal (CD28.2) (8)
  91. Monoclonal (CD333D6) (23)
  92. Monoclonal (CD336C5/2) (23)
  93. Monoclonal (CD84.1.21) (3)
  94. Monoclonal (CH2) (6)
  95. Monoclonal (CHD43F2/4) (23)
  96. Monoclonal (CLB-GB11) (2)
  97. Monoclonal (CLB-gran/12) (1)
  98. Monoclonal (CLB-MPO-1/1) (2)
  99. Monoclonal (CRIS1) (5)
  100. Monoclonal (CT14.G4) (23)
  101. Monoclonal (D5) (23)
  102. Monoclonal (DG1/447 + C117/370) (23)
  103. Monoclonal (DR-4-02) (3)
  104. Monoclonal (DREG56) (2)
  105. Monoclonal (DT101+ BC199) (23)
  106. Monoclonal (E29) (23)
  107. Monoclonal (EBVCS-5) (3)
  108. Monoclonal (EM-04) (4)
  109. Monoclonal (EM-05) (6)
  110. Monoclonal (EM-07) (3)
  111. Monoclonal (ERb455) (23)
  112. Monoclonal (F1G4) (23)
  113. Monoclonal (FGK45) (23)
  114. Monoclonal (FN50) (7)
  115. Monoclonal (G-23) (1)
  116. Monoclonal (G233) (1)
  117. Monoclonal (G28-8) (2)
  118. Monoclonal (G3.1) (23)
  119. Monoclonal (G4E4) (23)
  120. Monoclonal (GHI/61) (3)
  121. Monoclonal (GK1.5) (28)
  122. Monoclonal (GL-1) (3)
  123. Monoclonal (GP1.4) (23)
  124. Monoclonal (H146-968) (2)
  125. Monoclonal (H4B4) (3)
  126. Monoclonal (H57-597) (1)
  127. Monoclonal (Ham151-149) (1)
  128. Monoclonal (HB15e) (3)
  129. Monoclonal (HCG/52) (23)
  130. Monoclonal (HCGa/53) (23)
  131. Monoclonal (HCGb/459) (23)
  132. Monoclonal (HCGb/54) (23)
  133. Monoclonal (HD30) (2)
  134. Monoclonal (HHF35) (23)
  135. Monoclonal (HI149) (4)
  136. Monoclonal (HI186) (5)
  137. Monoclonal (HI30) (3)
  138. Monoclonal (HI40a) (3)
  139. Monoclonal (HI62P) (2)
  140. Monoclonal (HIM3-4) (3)
  141. Monoclonal (HIP1) (3)
  142. Monoclonal (HIP2) (1)
  143. Monoclonal (HIP8) (1)
  144. Monoclonal (HIT2) (12)
  145. Monoclonal (HL-38) (3)
  146. Monoclonal (HL-39) (1)
  147. Monoclonal (HL-40) (1)
  148. Monoclonal (HM57) (3)
  149. Monoclonal (HM79) (3)
  150. Monoclonal (Hs-3) (1)
  151. Monoclonal (htr9) (23)
  152. Monoclonal (IM7) (2)
  153. Monoclonal (IP26) (6)
  154. Monoclonal (IPO-38) (23)
  155. Monoclonal (IS7) (6)
  156. Monoclonal (IVA103) (1)
  157. Monoclonal (IVA285-1) (1)
  158. Monoclonal (IVA35) (1)
  159. Monoclonal (IVA50) (1)
  160. Monoclonal (IVA94) (1)
  161. Monoclonal (JJ319) (1)
  162. Monoclonal (K8.8 + DC10) (23)
  163. Monoclonal (KLC709) (23)
  164. Monoclonal (KP1 + C68/684) (23)
  165. Monoclonal (L17F12) (2)
  166. Monoclonal (L243) (3)
  167. Monoclonal (LAT-01) (1)
  168. Monoclonal (LAT-1D1) (1)
  169. Monoclonal (LCK-01) (3)
  170. Monoclonal (LIME-06) (2)
  171. Monoclonal (LIME-10) (1)
  172. Monoclonal (LIV3G11; same as 7B18) (23)
  173. Monoclonal (LNK16) (4)
  174. Monoclonal (LST1/02) (1)
  175. Monoclonal (LT-TD180) (4)
  176. Monoclonal (LT10) (3)
  177. Monoclonal (LT19) (8)
  178. Monoclonal (LT2) (5)
  179. Monoclonal (LT20) (6)
  180. Monoclonal (LT21) (5)
  181. Monoclonal (LT27) (6)
  182. Monoclonal (LT95) (6)
  183. Monoclonal (M17/4) (3)
  184. Monoclonal (M18/2) (3)
  185. Monoclonal (M2-7C10 + M2-9E3) (23)
  186. Monoclonal (M241) (23)
  187. Monoclonal (M38) (4)
  188. Monoclonal (M5/114) (2)
  189. Monoclonal (MA2) (1)
  190. Monoclonal (mAb#33) (2)
  191. Monoclonal (MEL-14) (3)
  192. Monoclonal (MEM-01) (3)
  193. Monoclonal (MEM-04) (1)
  194. Monoclonal (MEM-06) (8)
  195. Monoclonal (MEM-09) (1)
  196. Monoclonal (MEM-102) (6)
  197. Monoclonal (MEM-108) (5)
  198. Monoclonal (MEM-111) (2)
  199. Monoclonal (MEM-112) (1)
  200. Monoclonal (MEM-115) (2)
  201. Monoclonal (MEM-118) (6)
  202. Monoclonal (MEM-12) (8)
  203. Monoclonal (MEM-122) (4)
  204. Monoclonal (MEM-123) (2)
  205. Monoclonal (MEM-129) (2)
  206. Monoclonal (MEM-131) (3)
  207. Monoclonal (MEM-136) (7)
  208. Monoclonal (MEM-140) (2)
  209. Monoclonal (MEM-143) (1)
  210. Monoclonal (MEM-147) (2)
  211. Monoclonal (MEM-148) (4)
  212. Monoclonal (MEM-15) (10)
  213. Monoclonal (MEM-154) (6)
  214. Monoclonal (MEM-158) (6)
  215. Monoclonal (MEM-16) (1)
  216. Monoclonal (MEM-166) (7)
  217. Monoclonal (MEM-168) (1)
  218. Monoclonal (MEM-171) (4)
  219. Monoclonal (MEM-18) (9)
  220. Monoclonal (MEM-180) (2)
  221. Monoclonal (MEM-181) (9)
  222. Monoclonal (MEM-186) (8)
  223. Monoclonal (MEM-226) (6)
  224. Monoclonal (MEM-229) (3)
  225. Monoclonal (MEM-233) (7)
  226. Monoclonal (MEM-238) (5)
  227. Monoclonal (MEM-241) (13)
  228. Monoclonal (MEM-25) (7)
  229. Monoclonal (MEM-258) (8)
  230. Monoclonal (MEM-259) (10)
  231. Monoclonal (MEM-260) (2)
  232. Monoclonal (MEM-262) (2)
  233. Monoclonal (MEM-263) (4)
  234. Monoclonal (MEM-268) (5)
  235. Monoclonal (MEM-269) (1)
  236. Monoclonal (MEM-28) (13)
  237. Monoclonal (MEM-31) (12)
  238. Monoclonal (MEM-32) (3)
  239. Monoclonal (MEM-43) (8)
  240. Monoclonal (MEM-43/5) (1)
  241. Monoclonal (MEM-48) (7)
  242. Monoclonal (MEM-53) (6)
  243. Monoclonal (MEM-55) (6)
  244. Monoclonal (MEM-56) (7)
  245. Monoclonal (MEM-57) (10)
  246. Monoclonal (MEM-59) (8)
  247. Monoclonal (MEM-61) (7)
  248. Monoclonal (MEM-63) (6)
  249. Monoclonal (MEM-65) (3)
  250. Monoclonal (MEM-68) (1)
  251. Monoclonal (MEM-78) (8)
  252. Monoclonal (MEM-81) (1)
  253. Monoclonal (MEM-83) (2)
  254. Monoclonal (MEM-85) (8)
  255. Monoclonal (MEM-87) (1)
  256. Monoclonal (MEM-92) (2)
  257. Monoclonal (MEM-97) (2)
  258. Monoclonal (MEM-98) (3)
  259. Monoclonal (MEM-E/02) (1)
  260. Monoclonal (MEM-E/06) (1)
  261. Monoclonal (MEM-E/07) (2)
  262. Monoclonal (MEM-E/08) (1)
  263. Monoclonal (MEM-G/1) (2)
  264. Monoclonal (MEM-G/11) (2)
  265. Monoclonal (MEM-G/2) (2)
  266. Monoclonal (MEM-G/4) (1)
  267. Monoclonal (MEM-G/9) (8)
  268. Monoclonal (MEM-M6/1) (6)
  269. Monoclonal (MEM-M6/2) (1)
  270. Monoclonal (MEM-M6/6) (1)
  271. Monoclonal (MF9) (23)
  272. Monoclonal (MGN185) (23)
  273. Monoclonal (mLIME-05) (1)
  274. Monoclonal (MR-1) (3)
  275. Monoclonal (MYC699) (23)
  276. Monoclonal (NAP-03) (1)
  277. Monoclonal (NAP-07) (2)
  278. Monoclonal (NF421) (23)
  279. Monoclonal (NVL-07) (1)
  280. Monoclonal (OCH1E5; same as HepPar-1) (23)
  281. Monoclonal (OKT3) (2)
  282. Monoclonal (OX-35 (IgG2a)) (1)
  283. Monoclonal (OX-8) (2)
  284. Monoclonal (P/T2) (23)
  285. Monoclonal (PC61.5.3) (4)
  286. Monoclonal (QBEnd-10) (4)
  287. Monoclonal (QBEND-10) (23)
  288. Monoclonal (R73) (2)
  289. Monoclonal (RFB-4) (23)
  290. Monoclonal (Rs4) (1)
  291. Monoclonal (RT97) (23)
  292. Monoclonal (SC-05) (1)
  293. Monoclonal (SHIP-01) (1)
  294. Monoclonal (SHIP-02) (1)
  295. Monoclonal (SLAM.4) (1)
  296. Monoclonal (SN3) (5)
  297. Monoclonal (SO1) (1)
  298. Monoclonal (SPM120) (23)
  299. Monoclonal (SPM123) (23)
  300. Monoclonal (SPM125) (23)
  301. Monoclonal (SPM130) (23)
  302. Monoclonal (SPM250) (23)
  303. Monoclonal (SPM469) (23)
  304. Monoclonal (SPM503) (23)
  305. Monoclonal (SPM505) (23)
  306. Monoclonal (SPM508) (23)
  307. Monoclonal (SPM523) (23)
  308. Monoclonal (SPM524) (23)
  309. Monoclonal (SPM543) (23)
  310. Monoclonal (SPM544) (23)
  311. Monoclonal (SPM545) (23)
  312. Monoclonal (SPM546) (23)
  313. Monoclonal (SPM547) (23)
  314. Monoclonal (SPM549) (23)
  315. Monoclonal (SPM550) (23)
  316. Monoclonal (SPM554) (23)
  317. Monoclonal (SPM558) (23)
  318. Monoclonal (SPM559) (23)
  319. Monoclonal (SPM568) (23)
  320. Monoclonal (SPM569) (23)
  321. Monoclonal (SPM569+SPM570) (23)
  322. Monoclonal (SPM570) (23)
  323. Monoclonal (SPM579) (23)
  324. Monoclonal (ST29) (23)
  325. Monoclonal (SYK-01) (1)
  326. Monoclonal (TAL4.1) (23)
  327. Monoclonal (TB28-2) (5)
  328. Monoclonal (TB5) (1)
  329. Monoclonal (TC2) (4)
  330. Monoclonal (TNF706) (23)
  331. Monoclonal (TR9) (4)
  332. Monoclonal (TRIM-04) (2)
  333. Monoclonal (UCH-L1) (23)
  334. Monoclonal (UCH-T1*) (23)
  335. Monoclonal (UCHL1) (4)
  336. Monoclonal (UCHT1) (10)
  337. Monoclonal (UT-1) (1)
  338. Monoclonal (utr1) (23)
  339. Monoclonal (UW60.1) (2)
  340. Monoclonal (V65) (3)
  341. Monoclonal (W6/32) (4)
  342. Monoclonal (WM15) (8)
  343. Monoclonal (WM16/71) (23)
  344. Monoclonal (WM53) (7)
  345. Monoclonal (YN1/1.7.4) (3)
  346. Monoclonal (ZAP-03) (1)
  347. Polyclonal (7130)
Host Species
  1. Goat (6984)
  2. Hamster (16)
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  4. Pig (1)
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