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Immune System Diseases

Immunology is the study of the immune system and its functions. This branch of biomedical science deals with the physiological aspects of the immune system as it keeps an organism healthy and/or disorders or dysfunctions of the immune system which cause disease. The immune system consists of many cells, tissues, and organs that can function together in order to protect the body against foreign attacks from invaders like bacteria, viruses, and other organisms such as parasites. When the immune system fails to function or malfunctions, problems arise. Allergies, autoimmunity, and immunodeficiency are common types of immune system dysfunction. An allergy is an immune response to a typically harmless substance which may not bother the typical person or organism. Allergies are hypersensitivity disorders of the immune system. Autoimmunity is a category of diseases in which a person's own immune system mistakenly attacks normal cells or tissues in their own body. It is a misdirected immune response that occurs when the immune system goes amiss and attacks its own body. Immunodeficiency and immune system disease exist when the immune system is compromised or even unable to effectively fight infection at all.

Histamine receptor 1 antibody binds against the histamine receptor protein. This receptor is a G-protein coupled receptor that mediates the contraction of smooth muscles, increases capillary permeability due to contraction of terminal venules, neurotransmission in the central nervous system, and catecholamine release from the adrenal medulla. Histamine receptor 1 belongs to the H1 subclass of histamine receptors and is found in peripheral tissues in the cell membrane. Anti-WAS or Anti-WASP antibody binds against the effector protein for Rho-type FTPases. It is also known as Wiskott Aldrich Syndrome (eczema thrombocytopenia) antibody. The target protein regulates the structure and workings of the actin cytoskeleton in the thymus and spleen. The Wiskott Aldrich Syndrome antibody target also regulates lymphocytes and platelet function. Defects in WAS are the cause of Wiskott-Aldrich syndrome, thrombocytopenia type 1, and neutropenia severe congenital X-linked. WAS affected individuals suffer from eczema, a low platelet count, immune deficiency, and bloody diarrhea. Thrombocytopenia is effectively a decreased number of blood platelets which increases one's potential for uncontrollable bleeding and reduced ability for blood clotting. Individuals affected with severe congenital neutropenia are prone to recurrent infections due to a deficiency of neutrophils. Neutrophils are a type of white blood cell that is responsible for reducing inflammation and fighting infection.

 
Product Number Title Applications Host Clonality
AC16-0033 Anti-CD4 Antibody ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-01 Anti-CD4 Antibody (AMCA) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-02 Anti-CD4 Antibody (AP) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-03 Anti-CD4 Antibody (APC) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-04 Anti-CD4 Antibody (APC-Cy5.5) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-05 Anti-CD4 Antibody (APC-Cy7) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-06 Anti-CD4 Antibody (Avidin) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-07 Anti-CD4 Antibody (Biotin) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-08 Anti-CD4 Antibody (BPE) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-09 Anti-CD4 Antibody (Cy3) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-10 Anti-CD4 Antibody (Cy5) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)
AC16-0033-11 Anti-CD4 Antibody (Cy5.5) ELISA, IHC(F), IHC(P), ICC, IF, IP, FC Rat Monoclonal (GK1.5)