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Hypoxia

Hypoxia occurs as a result of a lack of sufficient dissolved oxygen in the bodily tissues. This can occur in in the entire body as generalized hypoxia or in certain parts of the body in tissue or regional hypoxia. Hypoxia is caused by many different sources including altitude sickness, cardiac arrest, carbon monoxide poisoning, choking, and anemia. Symptoms of hypoxia include headaches, fatigue, shortness of breath, blue skin, and nausea. Treatment will depend on the type of hypoxia and severity of hypoxia one is suffering from. To counteract altitude sickness, one can hyperventilate to increase the oxygen pressure in the arteries, but this will not effectively increase the amount of oxygen in circulation. For this, oxygen therapy is necessary. Individuals living at higher altitudes do acclimate to the lower oxygen content which can help somewhat. However, living at higher altitudes for a long period of time will cause polycythemia which increases the number of red blood cells in circulation to counter-act the lower oxygen levels. This thickens the blood and runs the risk that the heart cannot effectively circulate it.

Anti-SOCS3 antibody binds against the target SOCS3. SOCS3 is expressed in the heart, placenta, skeletal muscle, peripheral blood leukocytes, lung, and kidney. It is a negative regulator of cytokines. Defects in SOCS3 are implicated in atopic dermatitis. Atopic dermatitis is a chronic skin disorder that involves scaly and itchy rashes. Symptoms include blisters, discharge, raw skin, redness, and inflammation. The anti-Von Hippel Lindau antibody has involvement in cancer, metabolism, transcription, and cell-cycle functions. Also known as the VHL antibody, it can bind to the von Hippel-Lindau ubiquitination complex. The target protein is involved in the ubiquitination and proteasomal degradation of the VHL complex. Defects in this complex cause von Hippel-Lindau disease, pheochromocytoma, and erythrocytosis familial type 2. VHL is a rare genetic disorder in which affected individuals develop abnormal tumor growth in multiple parts of the body. Pheochromocytoma is a rare tumor of the adrenal gland which results in excess spinephrine and norepinephrine transmission. It is characterized by irregular heart rate, upset metabolism, and blood pressure. Erythrocytosis familial type 2 is an autosomal recessive genetic disorder which causes red blood cells to increase in mass. Complications of this disease include peripheral thrombosis and cerebrovascular events.

 
Product Number Title Applications Host Clonality
AC15-0116 Anti-TGF beta Antibody ELISA, WB, IHC, ICC, IF Chicken Polyclonal
AC16-0021 Anti-MMP2 Antibody IHC(F), IHC(P), FC Mouse Monoclonal (42-5D11)
AC16-0023 Anti-MMP14 Antibody ELISA, WB, IHC(P) Mouse Monoclonal (114-1F2)
AC16-0025 Anti-MMP14 Antibody WB, IHC(P) Mouse Monoclonal (113-5B7)
AC16-0041 Anti-Visfatin Antibody ELISA, WB, IHC(F), IHC(P) Rat Monoclonal (14A5)
AC16-0055 Anti-VEGF Receptor 1 Antibody ELISA, WB, IHC(P), IP Rabbit Polyclonal
AC16-0062 Anti-ADFP Antibody WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (AP125)
AC16-0021-01 Anti-MMP2 Antibody (AMCA) IHC(F), IHC(P), FC Mouse Monoclonal (42-5D11)
AC16-0021-02 Anti-MMP2 Antibody (AP) IHC(F), IHC(P), FC Mouse Monoclonal (42-5D11)
AC16-0021-03 Anti-MMP2 Antibody (APC) IHC(F), IHC(P), FC Mouse Monoclonal (42-5D11)
AC16-0021-04 Anti-MMP2 Antibody (APC-Cy5.5) IHC(F), IHC(P), FC Mouse Monoclonal (42-5D11)
AC16-0021-05 Anti-MMP2 Antibody (APC-Cy7) IHC(F), IHC(P), FC Mouse Monoclonal (42-5D11)