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Host Virus Interactions

The way in which a body can resist or react to a viral infection will depend upon the interactions that occur between the virus and the host. The immune response or defenses on behalf of the host can act directly on the virus killing it or indirectly by altering the way in which the virus can replicate. These host virus interactions can be labeled inherent, induced, specific, and non-specific. Inherent barriers include the skin and mucous secretions. Induced barriers include the body's ability to spike a fever, lower pH, and the use of immune cells to counteract viral invasions (such as antibodies). Non-specific interactions include phagocytosis by non-discriminating macrophages or NK cells, while T-cells are specific cells that can play a major role in the recovery from viral infections. Ultimately, the interaction between host and virus can either be beneficial to the host or beneficial to the virus. To the virus's benefit, the viral replication cycle can be completed. To the host's benefit, the replication cycle is halted by removing the materials that the virus needs to replicate or by containing and digesting the virus.

Anti-FLVCR antibody binds against the target feline leukemia virus subgroup C cellular receptor. FLVCR functions as a heme transporter that exports cytoplasmic heme. Feline leukemia virus subgroup C cellular receptor also causes susceptibility to feline leukemia in vitro. FLVCR is localized in the cell membrane and specified in all hematopoietic tissues (including peripheral blood lymphocytes), pancreas, and kidney. FLVCR contains 555 amino acicds and 12 hydrophobic potential membrane-spanning sequences. Defects in feline leukemia virus subgroup C cellular receptor are the cause of posterior column ataxia with retinitis pigmentosa in humans and red cell erythroid aplasia (aplastic anemia) and feline leukemia virus in cats. Feline leukemia viruses are contagious infections in domestic cats that are proliferative, degenerative, and immunosuppressive. FelV type C is a mutant form of the FelV virus that occurs in about 1% of cats infected with feline leukemia and causes severe anemia. Symptoms of the feline leukemia virus include decreased immunity and progressive anemia. Many cats that come into contact with the virus (approx. 70%) will not develop the disorder because they will produce anti-FelV antibodies, like anti-flvcr antibody, and which will fight off the virus before the cat develops any symptoms. Red cell aplasia is a disorder of feline leukemia negative cats that is characterized by severe non-regenerative anemia and absence of erythroid cells in bone marrow. This disease is often fatal but can be treated with large amounts of immunosuppressive drugs over a long time period. Posterior column ataxia with retinitis pigmentosa is an autosomal recessive neurodegenerative disorder characterized by retinitis pigmentosa (an eye disease w/damage to the retina) and sensory ataxia (loss of coordination). Anti-PCID1 antibody binds against the target PCID1. PCID1 is localized in the cytoplasm and broadly expressed in many different tissues. PCID1 is a component of the eukaryotic translation initiation factor 3 complex. The elF-3 complex is required for the initiation of protein synthesis. Elevated levels of ELF3M are found in many different cancer lines. Inactivating the protein has shown to interfere with the herpes virus' ability to translate its mRNA ultimately preventing protein synthesis.

 
Product Number Title Applications Host Clonality
AC21-2698 Anti-UBN1 Antibody ELISA, WB Goat Polyclonal
AC21-2804 Anti-SIRT1 Antibody ELISA, WB Goat Polyclonal
AC21-2985 Anti-CREB3 Antibody ELISA, WB Goat Polyclonal
AC21-0376-01 Anti-MDA5 Antibody (AMCA) ELISA, WB, IHC Goat Polyclonal
AC21-0376-02 Anti-MDA5 Antibody (AP) ELISA, WB, IHC Goat Polyclonal
AC21-0376-03 Anti-MDA5 Antibody (APC) ELISA, WB, IHC Goat Polyclonal
AC21-0376-04 Anti-MDA5 Antibody (APC-Cy5.5) ELISA, WB, IHC Goat Polyclonal
AC21-0376-05 Anti-MDA5 Antibody (APC-Cy7) ELISA, WB, IHC Goat Polyclonal
AC21-0376-06 Anti-MDA5 Antibody (Avidin) ELISA, WB, IHC Goat Polyclonal
AC21-0376-07 Anti-MDA5 Antibody (Biotin) ELISA, WB, IHC Goat Polyclonal
AC21-0376-08 Anti-MDA5 Antibody (BPE) ELISA, WB, IHC Goat Polyclonal
AC21-0376-09 Anti-MDA5 Antibody (Cy3) ELISA, WB, IHC Goat Polyclonal