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Homologous Recombination

Homologous recombination is a genetic recombination which occurs when nucleotide sequences are exchanged between two similar or identical molecules of genetic material. Homologous recombination is useful to repair breaks in DNA or to produce novel combinations of DNA during gamete production (meiosis) in order to produce genetic variability for progeny cells and offspring. When homologous recombination is used to repair DNA, the end result is not in interest of genetic variability. Rather, the final product is as close to an exact copy of the initial genetic material that was damaged. This form of recombination does not involve a chromosomal crossover. In meiosis, however, chromosomal crossovers are commonly the mechanism of choice in order to create genetic variation in the form of recombinant chromosomes. Crossover occurs when matching chromosomes, that may contain different alleles or variations of the genetic material for the same genes, are cleaved by enzymes, switched, and reattached to the neighboring chromosome. Problems can occur when very similar sections of chromosomes are selected for recombination, creating oddly shaped and erroneous chromosomal end products.

Anti-RAD51C antibody binds against the target RAD51C which is a DNA repair protein that is essential for homologous recombination in DNA repair. RAD51C is localized in the cell cytoplasm and nucleus and expressed in a variety of tissues, with the highest expression in testis, heart muscle, spleen, and prostate. Defects in RAD51C are responsible for Fanconi anemia and breast-ovarian familial cancer. Fanconi anemia is a recessively inherited form of anemia that can lead to bone marrow failure (aplastic anemia). Individuals with Fanconi anemia are often born with physical symptoms like short stature, missing fingers, discolored skin, mental retardation, and heart defects. Often times, individuals suffering from Fanconi anemia will not have normal life expectancies although treatment with umbilical cord and bone marrow stem cells has shown promise. Familial breast-ovarian cancer is a genetic predisposition to cancer of the breast and cancer of the ovaries. Affected families are characterized by early onset breast cancer, bilateral cancers (occurrence of cancer in both breasts, both ovaries, or breast and ovaries), and breast cancer among men. Anti-Rad51L1 antibody binds against the target antigen Rad51L1 (DNA repair protein RAD51 homolog 2). RAD51L1 is localized in the nucleus and expressed in a wide range of tissues. DNA repair protein RAD51 homolog 2 is involved in the homologous recombination repair pathway. A chromosomal aberration involving RAD51L1 is found in pulmonary chondroid hamartoma and uterine leiomyoma. Chondroid hamartoma is characterized by benign tumors that contain mesenchymal and epithelial components. Individuals with uterine leiomyoma have fibroids on their uterine smooth muscle. The tumors are benign but can lead to extreme menstrual bleeding, anemia, and infertility.

 
Product Number Title Applications Host Clonality
AC21-2975 Anti-RPA70 Antibody ELISA, WB Goat Polyclonal
AC21-0271-01 Anti-RAD51C Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0271-02 Anti-RAD51C Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0271-03 Anti-RAD51C Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0271-04 Anti-RAD51C Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal
AC21-0271-05 Anti-RAD51C Antibody (APC-Cy7) ELISA, WB Goat Polyclonal
AC21-0271-06 Anti-RAD51C Antibody (Avidin) ELISA, WB Goat Polyclonal
AC21-0271-07 Anti-RAD51C Antibody (Biotin) ELISA, WB Goat Polyclonal
AC21-0271-08 Anti-RAD51C Antibody (BPE) ELISA, WB Goat Polyclonal
AC21-0271-09 Anti-RAD51C Antibody (Cy3) ELISA, WB Goat Polyclonal
AC21-0271-10 Anti-RAD51C Antibody (Cy5) ELISA, WB Goat Polyclonal
AC21-0271-11 Anti-RAD51C Antibody (Cy5.5) ELISA, WB Goat Polyclonal