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HLA-G Antibodies

HLA-G Antibodies

Abcore sells many HLA-G antibodies, many which are pre-conjugated to Biotin, FITC, Alexa Fluor® 488, R-Phycoerythrin (PE), Allophycocyanin (APC), and peroxidase. Currently, many of these are monoclonal HLA-G antibodies, but there are polyclonal HLA-G antibodies which are currently in development. If you have any questions about our antibodies against HLA-G, please contact us. Also, if we do not have the HLA-G antibodies you need, or you cannot find them in the marketplace, please consider using our custom antibody production services to create an antibody which will meet all of your requirements.

Human leukocyte antigen (HLA) is a member of non-classical HLA class I proteins. This class of proteins includes 3 proteins, HLA-E, HLA-F, and HLA-G. HLA-G differs from other proteins in this family due to the presence of multiple isoforms which are both membrane bound and soluble [1-4], limited protein variability [5] and it has both limited tissue expression [6,7] and is involved in modulation of the immune system [8]. HLA-G was first discovered when it was found to be involved with protecting a developing fetus from its mother’s immune system [9]. It is now implicated in a large number of research areas in immunology including transplanted organ rejection [10], cancerous tumor escape [11], and viral infections [12].

HLA-G primary transcript encodes for seven splice variants, four membrane bound (HLA-G1, HLA-G2, HLA-G3, and HLA-G4) and three cytoplasmic, soluble variants (HLA-G5, HLA-G6, and HLA-G7). HLA-G was originally described as only being present in fetal tissues, but recent research has shown that it is expressed in adult thymic medulla, immature erythroid cells, pancreas, cornea, and the nail matrix. Additionally, within a cell the expression of HLA-G can be concentrated on membrane patches which can be transplanted via trogocytosis from either antigen presenting cells (APC) to T cells, or from tumor cells to natural killer cells (NK). Once these concentrated patches of HLA-G membrane have been exchanged, it can inhibit the NK or T cells and is therefore immunosuppressive. Some of the known HLA-G receptors are CD8, ILT2 (Ig-like transcript 2), ILT4 (Ig-like transcript 4), and KIR2DL4 (Killer cell immunoglobulin-like receptor 2DL4), LILRB1 (Leukocyte immunoglobulin-like receptor subfamily B member 1), LILRB2 (Leukocyte immunoglobulin-like receptor subfamily B member 1), and CD158d [13-15].

 
Product Number Title Applications Host Clonality
11-291 Anti-HLA G Antibody WB, IHC(P) Mouse Monoclonal (MEM-G/1)
1F-432 Anti-HLA G Antibody (FITC) WB, IHC(F), IHC(P), FC Mouse Monoclonal (2A12)
11-436 Anti-HLA G Antibody WB, IHC(P) Mouse Monoclonal (MEM-G/2)
21-436 Anti-HLA G Antibody WB, IHC(P) Mouse Monoclonal (MEM-G/2)
10-437 Anti-HLA G Antibody ELISA, IHC, FC, FUNC Mouse Monoclonal (87G)
F1-437 Anti-HLA G Antibody ELISA, IHC, FC, FUNC Mouse Monoclonal (87G)
1B-437 Anti-HLA G Antibody (Biotin) ELISA, IHC, FC, FUNC Mouse Monoclonal (87G)
1F-437 Anti-HLA G Antibody (FITC) ELISA, IHC, FC, FUNC Mouse Monoclonal (87G)
A4-437 Anti-HLA G Antibody (Alexa Fluor® 488) ELISA, IHC, FC, FUNC Mouse Monoclonal (87G)
1P-437 Anti-HLA G Antibody (PE) ELISA, IHC, FC, FUNC Mouse Monoclonal (87G)
11-438 Anti-HLA G Antibody ELISA, IHC(F), ICC, IP, FC Mouse Monoclonal (01G)
1B-438 Anti-HLA G Antibody (Biotin) ELISA, IHC(F), ICC, IP, FC Mouse Monoclonal (01G)