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Histones

Histones are small proteins found in association with DNA in the chromatin of eukaryotes. Histones are found in the nucleus in the center of coiled DNA. Histones are composed of alkaline proteins. There are 5 main types of histones including H1/H5, H2A, H2B, H3, and H4. H2A, H2B, H3, and H4 are core histones while H1 and H5 are linkers. Core histones are essentially spools that allow DNA to become compacted and organized. Basically, the DNA is wrapped around the histones, and then the DNA-histone complexes are further wound around each other to form the eukaryotic chromosome. The composition of the histones is highly conserved across different species, which only emphasizes their important role in DNA storage.

Anti-PRDM9 antibody binds against the target PRDM9. PRDM9 is a methyltransferase that trimethylates certain histones during the meiotic phase of cell division. PRDM9 is localized in the nucleus of the cell, specifically in the chromosomes. Anti- CLLD8/SETDB2 antibody binds against the target chronic lymphocytic leukemia deletion region 8. CLLD8 is localized in the chromosome of cells in the nucleus and expressed in all cell types (although expressed in highest amounts in the heart, testis, and ovaries). Histone methyltransferase is involved in early development and mitosis and plays a role in chromosome condensation and segregation during mitosis.

 
Product Number Title Applications Host Clonality
AC21-2979-02 Anti-PRDM9 Antibody (AP) ELISA Goat Polyclonal
AC21-2979-15 Anti-PRDM9 Antibody (PE-Cy5) ELISA Goat Polyclonal
AC21-2979-16 Anti-PRDM9 Antibody (PE-Cy5.5) ELISA Goat Polyclonal
AC21-2979-17 Anti-PRDM9 Antibody (PE-Cy7) ELISA Goat Polyclonal
AC21-2979-18 Anti-PRDM9 Antibody (PerCP) ELISA Goat Polyclonal
AC21-2979-19 Anti-PRDM9 Antibody (PerCP-Cy5.5) ELISA Goat Polyclonal
AC21-2979-20 Anti-PRDM9 Antibody (Rhodamine) ELISA Goat Polyclonal
AC21-2979-21 Anti-PRDM9 Antibody (RPE) ELISA Goat Polyclonal
AC21-2979-22 Anti-PRDM9 Antibody (Streptavidin) ELISA Goat Polyclonal
AC21-2980-01 Anti-PRDM9 Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-2979-14 Anti-PRDM9 Antibody (HRP) ELISA Goat Polyclonal
AC21-2979-13 Anti-PRDM9 Antibody (Glucose Oxidase) ELISA Goat Polyclonal