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Helix Turn Helix

Protein families, or protein domain families, are groups of protein domains that are related somehow, usually by gene families or evolutionary parameters. Proteins within a family have common ancestors from which they descend. This gives proteins within the same domain family similar three-dimensional structures, functions, and sequence similarities. Between 40 and 65% of proteins known will show sequence similarity to other proteins. When sequence similarity is known, structural and functional similarity is assumed. Helix-turn-helix, or HTH, refers to the shape of a specific group of protein domains. The structure consists of 20 amino acids in common which form the 2 alpha-helices that are bound together by a short curved turn portion of protein. The 2nd helix is responsible for binding to DNA by way of hydrogen bonds and hydrophobic interactions.

Anti-IRF6 antibody binds against the target interferon regulatory factor 6. IRF6 is localized in the nucleus and the cytopolasm and expressed in normal mammary epithelial cells and is not expressed in breast cancer tissues. IRF6 is a DNA-binding transcriptional activator. Defects in IRF6 are the cause of van der Woude syndrome, popliteal pterygium syndrome, and orofacial cleft. Van der Woude syndrome is a condition that affects facial development. Affected individuals will have a cleft lip, a cleft palate, or both. Popliteal pterygium syndrome is a disorder characterized by abnormal development of the face, skin, and genitals. Anti-myf5 antibody binds against the target myogenic factor 5. Myf5 is localized in the nucleus and involved in muscle differentiation.

 

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