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Heart Disease Antibodies

The circulatory system is the organ system that assists in the passing of nutrients, hormones, and other molecules to and from cells in the body. The cardiovascular system is part of the circulatory system and distributes blood throughout an organism. The main components of the cardiovascular system are the heart, blood, and blood vessels. Cardiovascular disease is an abnormal function of the heart and/or blood vessels. It is a category of disease that includes coronary heart disease (heart attacks), cerebrovascular disease (stroke), blood pressure problems, peripheral artery disease, rheumatic heart disease, congenital heart disease, and heart failure. Heart disease is the leading cause of human deaths across the world. There are many forms of heart disease and many can be prevented by healthy lifestyle choices. Other causes include atherosclerosis (buildup of fatty plaques in arteries), heart defects, and microorganisms. Heart failure occurs when the heart cannot continue to supply the necessary oxygenated blood to the body. Heart attacks occur when coronary arteries build up with blood clots which completely or partially block the blood flow. A stroke occurs when arteries in the brain are narrowed or blocked by a clot or plaque. Aneurysms occur in other parts of the body, apart from the brain and heart, and are also due to blocked blood flow. Peripheral artery disease, or PAD, occurs when the extremities (legs, hands, etc) do not get enough blood flow. Sudden cardiac arrest also occurs and is somewhat unexpected. Tests for diagnostics include bloodwork, chest X-rays, electrocardiogram (ECG), echocardiogram, certain types of scans, and even heart biopsy. Lifestyle changes, including eating a healthy diet, refraining from drinking and smoking, and getting plenty of exercise, have shown to reverse of treat certain types of heart disease. Other treatment options include prescription medication and surgery.

Anti-ARH antibody binds against the target ARH. ARH is localized in the cytoplasm and expressed in the kidney, liver, placenta, brain, heart, muscle, colon, spleen, intestine, lung, and leukocytes. ARH is an adapter protein that is required for efficient endocytosis of the LDL receptor in hepatocytes and lymphocytes. Defects in ARH are the cause of autosomal recessive hypercholesterolemia. Autosomal recessive hypercholesterolemia is a rare disorder that is caused by a complete loss of function of the ARH adapter protein. This protein is required for the uptake of LDL (the “bad” cholesterol). ARH is characterized by increased cholesterol levels in the blood, deposition of cholesterol in the skin and tendons, and premature coronary artery disease. Anti-FTO antibody binds against the target FTO. FTO is a dioxygenase that repairs RNA and DNA by oxidative demethlyation. FTO is expressed in many tissues and very highly expressed in adrenal glands, the brain, the hypothalamus, and the pituitary gland. FTO contributes to the regulation of the global metabolic rate, energy expenditure, and energy homeostasis. FTO also contributes to the regulation of body size and body fat accumulation. Defects in FTO are the cause of growth retardation developmental delay coarse facies and early death (GFDDCFED). Growth retardation developmental delay coarse facies and early death is a rare syndrome characterized course facial features with anteverted nostrils, thin vermilion, prominent alveolar ridge, and a protruding tongue. Affected individuals suffer from intrauterine growth retardation and heart defects including ventricular septal defects, atrioventricular defects, and patent arteriousus with or without cardiomyopathy. Individuals with growth retardation developmental delay course facies and early death will usually die by the age of 3 years.

 
Product Number Title Applications Host Clonality
AC15-0119 Anti-Creatine Kinase MM Antibody ELISA, WB, IHC, ICC, IF Goat Polyclonal
AC15-0120 Anti-Apolipoprotein A I Antibody ELISA, WB, IHC, ICC, IF Goat Polyclonal
AC16-0039 Anti-NeuroD1 Antibody IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0049 Anti-FTO Antibody WB, IHC(F), ICC, IF, FC Rabbit Polyclonal
AC16-0062 Anti-ADFP Antibody WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (AP125)
AC16-0039-01 Anti-NeuroD1 Antibody (AMCA) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-02 Anti-NeuroD1 Antibody (AP) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-03 Anti-NeuroD1 Antibody (APC) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-04 Anti-NeuroD1 Antibody (APC-Cy5.5) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-05 Anti-NeuroD1 Antibody (APC-Cy7) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-06 Anti-NeuroD1 Antibody (Avidin) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-07 Anti-NeuroD1 Antibody (Biotin) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)