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Hamster Antibodies

Antibodies for research or other applications are produced in vivo with the help and assistance of the immune systems of many different host species. Usually, the host species of an antibody should be the same as the target species of the study. However, this may not always be possible. In this instance, species cross-reactivity can be predicted by choosing an antibody from a host species with as close of a similar sequence as possible. A hamster antibody is an antibody that is raised and derived from a hamster. The hamster’s immune system is utilized in order to produce antibodies against a target. At first, the hamster is inoculated or immunized by some sort of antigen (typically a protein). The hamster’s immune system reacts with this foreign substance as an invader. Thus, antibodies are produced against said antigen. Typically, many booster injections are given in order to maximize the amount of antibody produced. In order to test if the hamster is producing an adequate supply of antibodies, small amounts of blood can be drawn and tested. These samples are tested for titre (titer) or a range of the amount of antibody being produced by the hamster. Once an adequate titre is detected, blood is drawn and an antiserum is made. The antiserum contains antibodies as well as blood serum or plasma. Depending on the immunizing antigen, the antiserum can contain many different types of antibodies (polyclonal). The antiserum needs to be purified and the hamster antibodies can be extracted. These hamster antibodies are useful in many aspects of research for medical and other laboratory or scientific processes.

Anti-CD40L antibody, raised in goat, binds against the target CD40 ligand. CD40 ligand mediates B-cell proliferation. CD40 ligand is involved in immunoglobulin class switching. CD40 ligand is expressed in activated CD4+ T-lymphocytes which is secreted by the body and also localized in the cell membrane. Defects in CD4oLG are the cause of X-linked immunodeficiency with hyper-IgM type 1 (X-linked hyper IgM syndrome). X-linked hyper IgM syndrome affects the immune system and primarily affects males. Affected individuals have abnormal levels of antibodies. Depending on the antibody, affected individuals have either an excessive amount or not enough antibodies. These antibody abnormalities make it difficult ofr people with X-linked hyper IgM syndrome to fight off infections. CD3 antibody, raised in hamster, has been used in research regarding B cell lymphoma as well as brain tumors. The CD3 complex is a mediator of signal transduction localized on the cell membrane. Defects in CD3 and anti- CD3 antibody can cause several severe immunodeficiency disorders among a specific group of ailments characterized by low antibody levels and specific immunities due to poor T- cell development.

 
Product Number Title Applications Host Clonality
10-568 Anti-CD3 zeta Antibody WB, ICC, IP , FC Hamster Monoclonal (H146-968)
12-629 Anti-CD40L Antibody IHC, ICC, IP, FC, FUNC Hamster Monoclonal (MR-1)
11-629 Anti-CD40L Antibody IHC, ICC, IP, FC, FUNC Hamster Monoclonal (MR-1)
11-627 Anti-CD80 Antibody IHC(F), IP, FC, FUNC Hamster Monoclonal (16-10A1)
12-597 Anti-CD28 Antibody IHC(F), ICC, IP, FC, FUNC Hamster Monoclonal (37.51)
1P-584 Anti-CD79b Antibody (PE) WB, ICC, IP , FC Hamster Monoclonal (HM79)
1F-584 Anti-CD79b Antibody (FITC) WB, ICC, IP , FC Hamster Monoclonal (HM79)
11-584 Anti-CD79b Antibody WB, ICC, IP , FC Hamster Monoclonal (HM79)
1A-578 Anti-CD3 Antibody (APC) IHC(F), ICC, IP, FC, FUNC Hamster Monoclonal (145-2C11)
1F-578 Anti-CD3 Antibody (FITC) IHC(F), ICC, IP, FC, FUNC Hamster Monoclonal (145-2C11)
12-578 Anti-CD3 Antibody IHC(F), ICC, IP, FC, FUNC Hamster Monoclonal (145-2C11)
11-578 Anti-CD3 Antibody IHC(F), ICC, IP, FC, FUNC Hamster Monoclonal (145-2C11)