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Growth Factor Receptors

Growth factor receptors are receptors which bind against growth factors. A growth factor is a naturally occurring substance that can stimulate cell growth. There are many different types of growth factors including adrenomedullin, epidermal growth factor, fibroblast growth factor, hepatocyte growth factor, transforming growth factor, and tumor necrosis factor. Each type of growth factor has a specialized function or cellular process for which it can help regulate. The growth factor receptor domain is rich in cysteines and found in a variety of eukaryotic proteins. The receptor is involved in signal transduction by enzymes like tyrosine kinases. Despite the different types of growth factor receptors, they have a general structure containing a growth factor receptor domain as a di-sulphide bound fold containing a beta-hairpin with two adjacent di-sulphides.

Anti-erbB 3 antibody binds against the target receptor tyrosine protein kinase erbB 3. Erb B 3 is secreted by cells and also localized on the cell membrane. It is overexpressed in a subset of human mammary tumors, and expressed in epithelial tissues, and the brain. Defects in ERBB3 arte the cause of lethal congenital contracture syndrome type 2. Lethal congenital contracture syndrome, or multiple contracture syndrome, is an autosomal recessive genetic disorder which causes complete immobility of a fetus and ultimately results in fetal death. Anti-ALK antibody binds against the target anaplastic lymphoma kinase. ALK is localized on the membrane and expressed in the brain and central nervous system. Anaplastic lymphoma kinase is an orphan receptor with a tyrosine-protein kinase activity and plays a role in the normal development and function of the nervous system. Defects in ALK are found in a form of non-Hodgkin lymphoma and cause susceptibility to neuroblastoma type 3. Neuroblastoma is a malignant tumor that develops in nerve tissue. Other symptoms include bone pain, flushed skin, profuse sweating, loss of movement, problems with balance, and uncontrolled eye movements. Treatment includes radiation, chemotherapy, and possible surgery.

 
Product Number Title Applications Host Clonality
AC21-2731 Anti-GCSF Receptor Antibody ELISA Goat Polyclonal
AC21-2973 Anti-c-Kit Antibody ELISA, WB Goat Polyclonal
AC21-0766-01 Anti-ErbB 3 Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0766-02 Anti-ErbB 3 Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0766-03 Anti-ErbB 3 Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0766-04 Anti-ErbB 3 Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal
AC21-0766-05 Anti-ErbB 3 Antibody (APC-Cy7) ELISA, WB Goat Polyclonal
AC21-0766-06 Anti-ErbB 3 Antibody (Avidin) ELISA, WB Goat Polyclonal
AC21-0766-07 Anti-ErbB 3 Antibody (Biotin) ELISA, WB Goat Polyclonal
AC21-0766-08 Anti-ErbB 3 Antibody (BPE) ELISA, WB Goat Polyclonal
AC21-0766-09 Anti-ErbB 3 Antibody (Cy3) ELISA, WB Goat Polyclonal
AC21-0766-10 Anti-ErbB 3 Antibody (Cy5) ELISA, WB Goat Polyclonal