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Germline Stem Cells

Stem cells are undifferentiated cells that have the capability to differentiate into specialized cell types. Stem cells are found in embryos during the blastocyte phase and also in adult tissue. A blastocyte is a 4 or 5 day old embryo. These stem cells can be harvested from embryos produced during the in-vitro fertilization process which may not be implanted or used in assisted reproduction attempts. The harvesting of embryonic stem cells does destroy the embryo. Embryonic stem cells have the potential to become any cell in the body. Stem cells can also be harvested from umbilical cord blood during birth. These cells can be less malleable, but still useful in treating certain diseases, especially leukemias. The cord blood stem cells are picked out in a sea of other typical blood cells. Adult stem cells are found in organs that have the capability to renew or regenerate itself. Adult stem cells, or somatic stem cells, are most commonly found in bone marrow, brain tissue, blood, skeletal muscles, skin, teeth, and testis. Once removed from the body, however, adult stem cells quickly lose their ability to differentiate. Germline stem cells are stem cells that give rise to gametes.

Anti-Oct4 antibody (Anti-POU5F1 antibody) binds against the target Oct4. Oct4 is a transcription factor that binds to the octamer motif and forms a trimeric complex with SOX2 on DNA. This complex controls the expression of a number of genes involved in embryonic development. POU5F1 is expressed in the developing brain and localized in the nucleus. Anti-nanos homologue 1 antibody binds against the target NANOS1. NANOS1 is localized in the cytoplasm and expressed in the highest amounts in the testis and ovary. Nanos homologue 1 may act as a translational repressor which regulates translation of certain mRNAs by forming a complex with other subunits that can associate with the 3' end of the mRNA target.

 
Product Number Title Applications Host Clonality
AC16-0046 Anti-Oct4 Antibody WB Rabbit Polyclonal
AC16-0046-01 Anti-Oct4 Antibody (AMCA) WB Rabbit Polyclonal
AC16-0046-02 Anti-Oct4 Antibody (AP) WB Rabbit Polyclonal
AC16-0046-03 Anti-Oct4 Antibody (APC) WB Rabbit Polyclonal
AC16-0046-04 Anti-Oct4 Antibody (APC-Cy5.5) WB Rabbit Polyclonal
AC16-0046-05 Anti-Oct4 Antibody (APC-Cy7) WB Rabbit Polyclonal
AC16-0046-06 Anti-Oct4 Antibody (Avidin) WB Rabbit Polyclonal
AC16-0046-07 Anti-Oct4 Antibody (Biotin) WB Rabbit Polyclonal
AC16-0046-08 Anti-Oct4 Antibody (BPE) WB Rabbit Polyclonal
AC16-0046-09 Anti-Oct4 Antibody (Cy3) WB Rabbit Polyclonal
AC16-0046-10 Anti-Oct4 Antibody (Cy5) WB Rabbit Polyclonal
AC16-0046-11 Anti-Oct4 Antibody (Cy5.5) WB Rabbit Polyclonal