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FGF

Cancer metabolism is often times exploited and used for cancer treatments. The metabolism of cancer is often thought of as cancer’s weak spot. The metabolism of cancer is an extremely rapid, non-discriminative replicating process. This is what allows for it to take over and starve surrounding tissues of their nutrients. Typically, cells will use fuel within itself to carry out the cellular processes for which that cell is created. In cancer, this fuel is used specifically to replicate rather than carry out any other tasks. New aged cancer treatments are targeting metabolic reprogramming in an attempt to control the rate at which cancer can reproduce. Cancer growth factors are polypeptides that stimulate cell proliferation. They are major regulatory proteins controlling cell growth. The growth factors are rate limiting, meaning when their supplies are exhausted, growth comes to a halt or slows drastically. There are many types of growth factors like EGFs, FGFs, hormones, insulin and insulin-like, PDGFs, TGFs, TNFs, and VEGFs. FGF stands for fibroblast growth factor. Fibroblast growth factors are a family of growth factors involved in angiogenesis, wound healing, and embryonic development. FGF’s have many different functions and can complete many different functions on multiple cell types. They induce the formation of mesoderm in embryogenesis, and assist in limb and neural development. The FGF’s bind heparin and certain cell surface receptors that initiate the transduction of certain signals.

Anti-FGFR1 antibody binds against the target fibroblast growth factor receptor 1. FGFR1 is localized on the membrane, in the nucleus, and in the cytoplasm. It is expressed in astrocytoma, neuroblastoma, and adrenal cortex cell lines. FGFR1 is a receptor for basic fibroblast growth factor. Defects in FGFR1 are the cause of Pfeiffer syndrome, idiopathic hypogonadotropic hypogonadism, and trigonocephaly non-syndromic. Anti-FGFR2 antibody binds against the target fibroblast growth factor receptor 2. FGFR2 is a receptor for acidic and basic fibroblast growth factors. Fibroblast growth factor receptor 2 is localized on the cell membrane of cells and is also secreted. Defects in FGFR2 are the cause of Crouzon syndrome, Apert syndrome, Pfeiffer syndrome, and familial scaphocephaly syndrome. Crouzon syndrome, also known as branchial arch syndrome, is a genetic disorder in which some of the skull bones fuse together prematurely which prevents normal skull growth. Affected individuals have distinct facial features like bulging eyes, a beaked nose, and underdeveloped jaws. Apert syndrome, is similar to Crouzon syndrome. It is a genetic disorder that causes the skull bones to close earlier than normal and affects the shape of the head and face. Affected individuals may often also have fused fingers and fused toes. Pfeiffer syndrome and familial scaphocephaly syndrome, as well, have facial and cranial symptoms similar to those affected with Crouzon syndrome and branchial arch syndrome.

 
Product Number Title Applications Host Clonality
AC21-2764 Anti-FGF14 Antibody ELISA, WB Goat Polyclonal
AC21-2765 Anti-FGF13 Antibody ELISA, WB Goat Polyclonal
AC21-0574-01 Anti-Sprouty 1 Antibody (AMCA) ELISA, WB, IHC Goat Polyclonal
AC21-0574-02 Anti-Sprouty 1 Antibody (AP) ELISA, WB, IHC Goat Polyclonal
AC21-0574-03 Anti-Sprouty 1 Antibody (APC) ELISA, WB, IHC Goat Polyclonal
AC21-0574-04 Anti-Sprouty 1 Antibody (APC-Cy5.5) ELISA, WB, IHC Goat Polyclonal
AC21-0574-05 Anti-Sprouty 1 Antibody (APC-Cy7) ELISA, WB, IHC Goat Polyclonal
AC21-0574-06 Anti-Sprouty 1 Antibody (Avidin) ELISA, WB, IHC Goat Polyclonal
AC21-0574-07 Anti-Sprouty 1 Antibody (Biotin) ELISA, WB, IHC Goat Polyclonal
AC21-0574-08 Anti-Sprouty 1 Antibody (BPE) ELISA, WB, IHC Goat Polyclonal
AC21-0574-09 Anti-Sprouty 1 Antibody (Cy3) ELISA, WB, IHC Goat Polyclonal
AC21-0574-10 Anti-Sprouty 1 Antibody (Cy5) ELISA, WB, IHC Goat Polyclonal