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Extracellular Apoptosis Signals

Apoptosis is the process by which cells die a programmed death or PCD. The process is facilitated by processes within the cell using certain biochemicals that lead to changes in cell morphology and eventually leads to the cell dying. This is a natural process in the cell cycle and is necessary to maintain proper alignments of organ and organelle structure. Defects in the apoptosis of cells can lead to diseases such as cancer. Each cell must die in order to make room for fresh replacements. Apoptosis can also be useful in the breakdown of cells into their parts for recycling and re-use. It is essentially induction of cell suicide. Apoptosis can be triggered by internal or external signals. Externally, apoptosis receptors can activate intracellular kinases. These intracellular kinases can ultimately activate or inhibit proteins involved in apoptosis or even affect transcription factors. These apoptotic transcription factors can inhibit the expression of pro-apoptotic proteins or promote the expression of cell survival proteins.

Anti-PHAP12 / APRIL antibody binds against PHAP12 / APRIL. PHAP12 / APRIL is localized in the nucleus and expressed in the heart, lung, pancreas, prostate, spleen, thymus, and placenta. It is a multifunctional protein working as a cell cycle progression factor as well as a cell survival factor. Anti-FAIM1 antibody binds against the target fas apoptotic inhibitory molecule 1. FAIM1 is localized in the cytoplasm. It plays a role as an inducible effector molecule that mediates Fas resistance produced by surface immunoglobulin engagement in B cells.

 
Product Number Title Applications Host Clonality
AC21-0342-01 Anti-PHAPI2 / APRIL Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0342-02 Anti-PHAPI2 / APRIL Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0342-03 Anti-PHAPI2 / APRIL Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0342-04 Anti-PHAPI2 / APRIL Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal
AC21-0342-05 Anti-PHAPI2 / APRIL Antibody (APC-Cy7) ELISA, WB Goat Polyclonal
AC21-0342-06 Anti-PHAPI2 / APRIL Antibody (Avidin) ELISA, WB Goat Polyclonal
AC21-0342-07 Anti-PHAPI2 / APRIL Antibody (Biotin) ELISA, WB Goat Polyclonal
AC21-0342-08 Anti-PHAPI2 / APRIL Antibody (BPE) ELISA, WB Goat Polyclonal
AC21-0342-09 Anti-PHAPI2 / APRIL Antibody (Cy3) ELISA, WB Goat Polyclonal
AC21-0342-10 Anti-PHAPI2 / APRIL Antibody (Cy5) ELISA, WB Goat Polyclonal
AC21-0342-11 Anti-PHAPI2 / APRIL Antibody (Cy5.5) ELISA, WB Goat Polyclonal
AC21-0342-12 Anti-PHAPI2 / APRIL Antibody (FITC) ELISA, WB Goat Polyclonal