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Epigenetics and Nuclear Antibodies

Epigenetics is the study of heritable changes in the expression of genes that are not directly related to the sequence of the DNA. There are a wide array of epigenetic mechanisms that can affect many biological processes and definite phenotypes. Epi- the prefix meaning above- genetics is based around the non-genetic cellular memory which can record developmental and environmental cues. This non-genetic memory can differ among cells of identical DNA sequences and thus result in cells of differing phenotypes, or observable characteristics. Most epigenetic systems are heritable, self-perpetuating, and reversible. These can include processes such as methylation, acetylation, ubiquitylation, and phosphorylation. Specific examples of systems affected by epigenetic processes include imprinting, gene silencing, reprogramming, and epigenetic cancer.

Anti-FOXC1 antibody binds against FOXC1. FOXC1 is a forkhead box protein that binds FREAC-3 and FREAC-4 to their sites on DNA. This process results in the bending of DNA at an 80-90 degree angle. FOXC1 is localized in the nucleus of a cell and expressed in all tissues and cell lines. Defects in FOXC1 are the cause of Axenfeld-Rieger syndrome type 3, iridogoniodysgenesis, and Peter’s anomaly. Axenfeld-Rieger syndrome type 3 is a disorder of the eye. Axenfeld-Rieger syndrome type 3 is an autosomal dominant disorder in which affected individuals often have abnormalities of the iris, pupil, and teeth in addition to a glaucoma (found in 50% of diagnosed individuals). Iridogoniodysgenesis is a hereditary ocular disease characterized by unusually dark irises and often times glaucoma. Peter’s anomaly is a very rare disorder which causes corneal opacity which effectively decreases the ability to see to the point of near or complete blindness. Anti-PMS1 antibody binds against the target PMS1 antigen. PMSI is localized in the nucleus and is involved in the repair of mismatches in DNA. Defects in PMS1 are the cause of hereditary non-polyposis colorectal cancer type 3. Hereditary non-polyposis colorectal cancer type 3 is also called Lynch syndrome and is a form of inherited colon cancer.

 
Product Number Title Applications Host Clonality
AC16-0036 Anti-SOX17 Antibody ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0038 Anti-MyoD1 Antibody ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC1-C2H8)
AC16-0039 Anti-NeuroD1 Antibody IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0043 Anti-5-hydroxymethylcytosine (5-hmC) Antibody WB, IHC(F), IHC(P) Mouse Monoclonal (4D9)
AC16-0044 Anti-Histone H3 (phospho S10) Antibody WB Rabbit Polyclonal
AC16-0045 Anti-KLF4 Antibody ELISA, WB Rabbit Polyclonal
AC16-0046 Anti-Oct4 Antibody WB Rabbit Polyclonal
AC16-0047 Anti-p53 Antibody ELISA, WB, IHC(F), IHC(P) Rabbit Polyclonal
AC16-0072 Anti-BrdU Antibody WB, IHC(F), IHC(P), ICC, IF, FC Rat Monoclonal (BU1/75)
AC16-0073 Anti-5-methylcytosine (5-mC) Antibody WB Mouse Monoclonal (33D3)
AC16-0036-01 Anti-SOX17 Antibody (AMCA) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-02 Anti-SOX17 Antibody (AP) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
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Category
  1. Chromatin Binding Proteins (1967)
  2. Chromatin Modifying Enzymes (1560)
  3. Chromatin Remodeling (534)
  4. Chromosome Structure (923)
  5. DNA and RNA Related (5324)
  6. DNA Methylation (349)
  7. Histones (95)
  8. Nuclear Signaling (2660)
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  10. Transcription (11867)
Application
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  12. IP (1981)
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  14. WB (16020)
Conjugate
  1. Alexa FluorÔö¼┬½ 488 (1)
  2. Alexa FluorÔö¼┬½ 647 (1)
  3. AMCA (965)
  4. AP (965)
  5. APC (965)
  6. APC-Cy5.5 (965)
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  22. PE-Dyomics 647 (1)
  23. PerCP (965)
  24. PerCP-Cy5.5 (965)
  25. Peroxidase (1)
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  27. RPE (965)
  28. Streptavidin (965)
Clonality
  1. Monoclonal (1/24) (23)
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  3. Monoclonal (1D12/4) (23)
  4. Monoclonal (1E8-G6) (23)
  5. Monoclonal (1SS-48) (23)
  6. Monoclonal (2H12/4) (23)
  7. Monoclonal (33D3) (23)
  8. Monoclonal (3E2D10 + VWF635) (23)
  9. Monoclonal (3E2D10) (23)
  10. Monoclonal (3G3) (4)
  11. Monoclonal (4-6G) (23)
  12. Monoclonal (46B11) (23)
  13. Monoclonal (4D9) (23)
  14. Monoclonal (5E6/2) (23)
  15. Monoclonal (6-36) (23)
  16. Monoclonal (6-37) (23)
  17. Monoclonal (66.4.C2; same as PN-15) (23)
  18. Monoclonal (6D7) (23)
  19. Monoclonal (6E1) (23)
  20. Monoclonal (6F11/2) (23)
  21. Monoclonal (9E10) (3)
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  23. Monoclonal (A6/2/2) (23)
  24. Monoclonal (ABRA1-01) (1)
  25. Monoclonal (AC8.3) (23)
  26. Monoclonal (AE-1) (23)
  27. Monoclonal (AE-20) (23)
  28. Monoclonal (AER314) (23)
  29. Monoclonal (Ali12-28) (23)
  30. Monoclonal (AN4.3) (23)
  31. Monoclonal (AP2a8G8/5) (23)
  32. Monoclonal (ARF4C6/4) (23)
  33. Monoclonal (ATM11G12) (23)
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  39. Monoclonal (BP53-12) (2)
  40. Monoclonal (BRG-01) (1)
  41. Monoclonal (BU1/75) (1)
  42. Monoclonal (Bu20a) (1)
  43. Monoclonal (C-04; same as Ks18.04) (23)
  44. Monoclonal (C-43) (23)
  45. Monoclonal (C-J4C4/1) (23)
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  48. Monoclonal (C5) (1)
  49. Monoclonal (C6) (1)
  50. Monoclonal (C6/372) (23)
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  54. Monoclonal (cdc69H8/5) (23)
  55. Monoclonal (CHD43F2/4) (23)
  56. Monoclonal (COL-1) (23)
  57. Monoclonal (Cor10G11/7) (23)
  58. Monoclonal (CP9/19) (23)
  59. Monoclonal (CTD8A7) (23)
  60. Monoclonal (CV5.1) (23)
  61. Monoclonal (D5) (23)
  62. Monoclonal (DAXX-01) (1)
  63. Monoclonal (DAXX-03) (1)
  64. Monoclonal (DCS118) (23)
  65. Monoclonal (DCS211.6) (23)
  66. Monoclonal (DF1513) (23)
  67. Monoclonal (E2-E3+2D11-H5; same as INS04+INS05) (23)
  68. Monoclonal (E23.1) (23)
  69. Monoclonal (E67) (23)
  70. Monoclonal (E67.1) (23)
  71. Monoclonal (EM-11) (1)
  72. Monoclonal (EP190b) (23)
  73. Monoclonal (ESEE122) (23)
  74. Monoclonal (FAT-13D7/1) (23)
  75. Monoclonal (FP3.2 [FPS392]) (1)
  76. Monoclonal (GFR450) (23)
  77. Monoclonal (H-RAS-03) (1)
  78. Monoclonal (H1) (23)
  79. Monoclonal (H1+TS1) (23)
  80. Monoclonal (Ha111a) (23)
  81. Monoclonal (HAF1010D3/8) (23)
  82. Monoclonal (HCGb/54+ HCGb/459) (23)
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  85. Monoclonal (JCB117) (23)
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  87. Monoclonal (K8/383) (23)
  88. Monoclonal (KP1) (23)
  89. Monoclonal (LH2) (23)
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  92. Monoclonal (MEM-54) (2)
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  94. Monoclonal (MoBu-1) (1)
  95. Monoclonal (MTA302G10/3) (23)
  96. Monoclonal (NP4D6) (3)
  97. Monoclonal (P/T1) (23)
  98. Monoclonal (Pab1801) (23)
  99. Monoclonal (Pab1802) (23)
  100. Monoclonal (Pab240) (23)
  101. Monoclonal (PAG-C1) (1)
  102. Monoclonal (POH-1) (1)
  103. Monoclonal (PSM1) (1)
  104. Monoclonal (Rad544E3/1) (23)
  105. Monoclonal (RAP14C8/1) (23)
  106. Monoclonal (Rb1(1F8)) (23)
  107. Monoclonal (SB46) (23)
  108. Monoclonal (SH54) (23)
  109. Monoclonal (SM1) (1)
  110. Monoclonal (SM2) (1)
  111. Monoclonal (SO1) (1)
  112. Monoclonal (SPM144) (23)
  113. Monoclonal (SPM150) (23)
  114. Monoclonal (SPM166) (23)
  115. Monoclonal (SPM348) (23)
  116. Monoclonal (SPM350) (23)
  117. Monoclonal (SPM354) (23)
  118. Monoclonal (SPM427) (23)
  119. Monoclonal (SPM442) (23)
  120. Monoclonal (SPM453) (23)
  121. Monoclonal (SPM456) (23)
  122. Monoclonal (SPM537) (23)
  123. Monoclonal (SPM564) (23)
  124. Monoclonal (SPM566) (23)
  125. Monoclonal (SPM567) (23)
  126. Monoclonal (SPM579) (23)
  127. Monoclonal (SPM587) (23)
  128. Monoclonal (SPM589) (23)
  129. Monoclonal (SPM590) (23)
  130. Monoclonal (SX53G8) (23)
  131. Monoclonal (TC-113) (23)
  132. Monoclonal (TC-14) (23)
  133. Monoclonal (TC-19) (23)
  134. Monoclonal (TS1) (23)
  135. Monoclonal (UBN1-02) (1)
  136. Monoclonal (V92.1) (23)
  137. Monoclonal (VM452) (23)
  138. Monoclonal (VWF635) (23)
  139. Monoclonal (WA-1) (1)
  140. Monoclonal (X29.2) (23)
  141. Monoclonal (Y100.4) (23)
  142. Polyclonal (19746)
Host Species
  1. Goat (19483)
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  3. Rabbit (262)
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