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Ectoderm Markers

The ectoderm is one of the three germ layers of the developing animal embryo. It is the first layer to emerge during gastrulation. The ectoderm is the outermost layer. The ectoderm contains cells that go on to form the immune system including the spine, peripheral nerves, and the brain. Ectoderm cells also contribute to the formation of the skin cells in the epidermis and pigment cells. Ectodermal lineage markers are used to study the ectodermal cells and determine which cells go where when forming the organs and tissues. These markers assist in mapping the stages of the ectoderm differentiation during development. Ectodermal lineages include oligodendrocytes, type-1 and type-2 astrocytes, and neuron progenitors.

Anti-pax3 antibody binds against the target pax3 (paired box protein 3). Pax3 functions as a transcription factor associated with the development of alveolar rhabdomyosarcoma. Paired box protein 3 is localized in the cell nucleus. Defects in PAX3 are the cause of Waardenburg syndrome, craniofacial-deafness-hand syndrome, and rhabdomyosarcoma. Waardenburg syndrome is a genetic syndrome with a variety of related defects. Waardenburg syndrome is characterized by partial albinism, wide set eyes, and deafness. Craniofacial-deafness-hand syndrome is characterized by distinctive facial features, hearing loss, and hand abnormalities. Affected individuals have a flat facial profile, slit like nostrils, and loss of hearing. Rhabdomyosarcoma is a cancerous tumor that is attached to the bone inside of the muscle. Rhabdomyosarcoma is a rare form of cancer treated with radiation or chemotherapy or a combination of both. Anti-FGFR2 antibody binds against the target fibroblast growth factor receptor 2. FGFR2 is a receptor for acidic and basic fibroblast growth factors. Fibroblast growth factor receptor 2 is localized on the cell membrane of cells and is also secreted. Defects in FGFR2 are the cause of Crouzon syndrome, Apert syndrome, Pfeiffer syndrome, and familial scaphocephaly syndrome. Crouzon syndrome, also known as branchial arch syndrome, is a genetic disorder in which some of the skull bones fuse together prematurely which prevents normal scull growth. Affected individuals have distinct facial featurs like bulging ees, beaked nose, and underdeveloped jaws. Apert syndrome, is similar to Crouzon syndrome. It is a genetic disorder that causes the skull bones to close earlier than normal and affects the shape of the head and face. Affected individuals may often also have fused fingers and fused toes. Pfeiffer syndrome and familial scaphocephaly syndrome, as well, have facial and cranial symptoms similar to those affected with Crouzon syndrome and branchial arch syndrome.

 
Product Number Title Applications Host Clonality
AC21-2642 Anti-PAX3 Antibody ELISA, WB Goat Polyclonal
AC21-2815 Anti-SOX10 Antibody ELISA, WB Goat Polyclonal
AC21-0234-01 Anti-GATA3 Antibody (AMCA) ELISA, WB, IHC Goat Polyclonal
AC21-0234-02 Anti-GATA3 Antibody (AP) ELISA, WB, IHC Goat Polyclonal
AC21-0234-03 Anti-GATA3 Antibody (APC) ELISA, WB, IHC Goat Polyclonal
AC21-0234-04 Anti-GATA3 Antibody (APC-Cy5.5) ELISA, WB, IHC Goat Polyclonal
AC21-0234-05 Anti-GATA3 Antibody (APC-Cy7) ELISA, WB, IHC Goat Polyclonal
AC21-0234-06 Anti-GATA3 Antibody (Avidin) ELISA, WB, IHC Goat Polyclonal
AC21-0234-07 Anti-GATA3 Antibody (Biotin) ELISA, WB, IHC Goat Polyclonal
AC21-0234-08 Anti-GATA3 Antibody (BPE) ELISA, WB, IHC Goat Polyclonal
AC21-0234-09 Anti-GATA3 Antibody (Cy3) ELISA, WB, IHC Goat Polyclonal
AC21-0234-10 Anti-GATA3 Antibody (Cy5) ELISA, WB, IHC Goat Polyclonal