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Domain Families

Protein families, or protein domain families, are groups of protein domains that are related somehow, usually by gene families or evolutionary parameters. Proteins within a family have common ancestors from which they descend. This gives proteins within the same domain family similar three-dimensional structures, functions, and sequence similarities. Between 40 and 65% of proteins known will show sequence similarity to other proteins. When sequence similarity is known, structural and functional similarity is assumed. Examples of protein domain families include ABC transporters, Arf family, cyclins, and zinc fingers.

Anti-PAX5 antibody binds against the PAX5 target. Pax 5 plays a role in B-cell differentiation, neural development, and spermatogenesis. PAX5, or paired box 5, is localized in the nucleus. A chromosomal error involving the gene that encodes for paired box 5 is involved in acute lymphoblastic leukemia. Acute lymphoblastic leukemia is a rapidly progressing form of blood cancer which is characterized by an accumulation of useless and immature blood and bone marrow cells. Symptoms of ALL include fatigue, high fever, pain, swollen glands, and weight loss. Treatment for acute lymphoblastic leukemia typically involves chemotherapy and sometimes stem cell transplants or bone marrow transplants. Anti-PRDM16 antibody binds against the target PRDM16. PRDM16 functions as a transcriptional regulator that binds to DNA. PRDM16 is localized in the cell nucleus and expressed in the cells of the uterus and kidney. PRDM16 functions in the differentiation of brown adipose (fat) tissue. The target specializes in dissipating chemical energy as heat in response to cold temperatures or excessive white adipose (fat) tissue metabolism. Defects with PRDM16 (chromosomal aberration) are involved in myelodysplastic syndrome and acute myeloid leukemia. Myelodysplastic syndromes are a group of diseases in which the bone marrow does not function properly. In individuals with myelodysplastic syndromes, their bone marrow does not make enough healthy blood cells. There are multiple types of MDS which are characterized by the appearance and types of blood cells that the bone marrow does produce. Treatment is available for MDS and includes chemotherapy, stem cell transplants, and use of growth factors. Acute myeloid leukemia is a cancer that also involves the bone marrow. AML is characterized by an abnormal accumulation of white blood cells in the bone barrow which interfere with the body's ability to produce normal blood cells. Treatment of AML typically consists of chemotherapy and in extreme cases, hematopoietic stem cell transplants.

 
Product Number Title Applications Host Clonality
AC16-0036 Anti-SOX17 Antibody ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0038 Anti-MyoD1 Antibody ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC1-C2H8)
AC16-0039 Anti-NeuroD1 Antibody IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0045 Anti-KLF4 Antibody ELISA, WB Rabbit Polyclonal
AC16-0046 Anti-Oct4 Antibody WB Rabbit Polyclonal
AC16-0036-01 Anti-SOX17 Antibody (AMCA) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-02 Anti-SOX17 Antibody (AP) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-03 Anti-SOX17 Antibody (APC) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-04 Anti-SOX17 Antibody (APC-Cy5.5) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-05 Anti-SOX17 Antibody (APC-Cy7) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-06 Anti-SOX17 Antibody (Avidin) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-07 Anti-SOX17 Antibody (Biotin) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
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