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DNA and RNA Related

DNA, deoxyribonucleic acid, is the genetic material that contains the instructions used for development and performance in almost all living organisms. The information, or genes, exist as two complimentary strands arranged next to each other in opposite directions and attached by rungs in the center to form a ladder type orientation which is further twisted into the DNA double helix. DNA inside of cells contains a large amount of information and is often times organized into chromosomes, or plasmids (in bacteria). The genes are duplicated during cell division in the process called DNA replication, so that progeny cells may have copies of genetic material as well. RNA, ribonucleic acid, is also a nucleic acid that is essential for life. RNA and DNA have similar compositions of nucleotides but differ in many respects. RNA is single stranded, contains ribose (not deoxyribose), and has a unique nucleotide called uracil in place of thymine. RNA has many important functions in the body. Messenger RNA, mRNA, is involved in translation. Transfer RNA (tRNA) and ribosomal RNA (rRNA) are involved in protein synthesis.

Anti-PMS1 antibody binds against the target PMS1 antigen. PMSI is localized in the nucleus and is involved in the repair of mismatches in DNA. Defects in PMS1 are the cause of hereditary non-polyposis colorectal cancer type 3. Hereditary non-polyposis colorectal cancer type 3 is also called Lynch syndrome and is a form of inherited colon cancer. Anti-PRPF31 antibody binds against pre mRNA processing factor 31 homolog. Pre mRNA processing factor 31 homolog is involved in pre-mRNA splicing and is required for U4/U6 tri-snRNP formation. PRPF31 is localized in the nucleus speckle and cajal bodies and is ubiquitously expressed in all bodily tissues. Defects in PRPF31 are the cause of retinitis pigmentosa type 11. Retinitis pigmentosa type 11 is an autosomal dominant disorder characterized by a progressive loss of photoreceptors in the retina. Affected individuals suffer from night blindness, tunnel vision, blurry vision, and extreme tiredness. Retinitis pigmentosa is a degenerative disorder that continually worsens as the individual grows older. Those affected appear physically normal.

 
Product Number Title Applications Host Clonality
AC16-0043 Anti-5-hydroxymethylcytosine (5-hmC) Antibody WB, IHC(F), IHC(P) Mouse Monoclonal (4D9)
AC16-0047 Anti-p53 Antibody ELISA, WB, IHC(F), IHC(P) Rabbit Polyclonal
AC16-0072 Anti-BrdU Antibody WB, IHC(F), IHC(P), ICC, IF, FC Rat Monoclonal (BU1/75)
AC16-0073 Anti-5-methylcytosine (5-mC) Antibody WB Mouse Monoclonal (33D3)
AC16-0043-01 Anti-5-hydroxymethylcytosine (5-hmC) Antibody (AMCA) WB, IHC(F), IHC(P) Mouse Monoclonal (4D9)
AC16-0043-02 Anti-5-hydroxymethylcytosine (5-hmC) Antibody (AP) WB, IHC(F), IHC(P) Mouse Monoclonal (4D9)
AC16-0043-03 Anti-5-hydroxymethylcytosine (5-hmC) Antibody (APC) WB, IHC(F), IHC(P) Mouse Monoclonal (4D9)
AC16-0043-04 Anti-5-hydroxymethylcytosine (5-hmC) Antibody (APC-Cy5.5) WB, IHC(F), IHC(P) Mouse Monoclonal (4D9)
AC16-0043-05 Anti-5-hydroxymethylcytosine (5-hmC) Antibody (APC-Cy7) WB, IHC(F), IHC(P) Mouse Monoclonal (4D9)
AC16-0043-06 Anti-5-hydroxymethylcytosine (5-hmC) Antibody (Avidin) WB, IHC(F), IHC(P) Mouse Monoclonal (4D9)
AC16-0043-07 Anti-5-hydroxymethylcytosine (5-hmC) Antibody (Biotin) WB, IHC(F), IHC(P) Mouse Monoclonal (4D9)
AC16-0043-08 Anti-5-hydroxymethylcytosine (5-hmC) Antibody (BPE) WB, IHC(F), IHC(P) Mouse Monoclonal (4D9)
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  1. DNA and Nucleotides (236)
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