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Diabetes Antibodies

Metabolism is the biochemical process by which an organism converts what it ingests into energy. This energy is used for many biological processes like thinking, growing, breathing, and pumping blood to all the organs in the body. Metabolism is a constant process as metabolic reactions are concurrently occurring in the body and cells at the same time, all the time. The endocrine system plays a very important role in metabolism. Many glands and hormones of the endocrine system are involved in controlling the rate and direction of metabolism. The thyroid and the pancreas, most importantly, help to produce hormones like thyroxine and insulin to control a body’s metabolism. Each person has a different basal metabolic rate. Metabolic diseases or metabolic disorders are a group of diseases that are caused by abnormal chemical reactions in the body’s cells. The organs can malfunction in their production of certain metabolic enzymes or hormones or the enzymes or hormones themselves can fail to function properly. Examples of metabolic disorders include galactosemia, diabetes, hyperthyroidism, hypothyroidism, and phenylketonuria. Diabetes is a chronic disorder that allows for high levels of sugar in the bloodstream. There are two types of diabetes; Type 1 is typically referred to as juvenile diabetes or insulin dependent diabetes. Type 1 diabetes is a form of autoimmune disorder in which affected individuals cannot produce insulin due to the destruction of the insulin producing beta cells in the pancreas. Type 2 diabetes is typically developed later in life due to diet and lifestyle choices. Type 2 diabetes is often called insulin resistance and it occurs when the body stops responding properly to the insulin produced which also can lead to an increased amount of sugar in the blood.

Anti-FTO antibody binds against FTO. FTO is a dioxygenase responsible for repairing alkylated DNA and RNA. FTO, also called protein fatso, contributes to the regulation of body size and body fat accumulation. The protein is called fatso because it is encoded by a very large gene. FTO is ubiquitously expressed although in higher amounts in the adrenal glands, brain, hypothalamus, and pituitary gland. Defects in FTO cause growth retardation developmental delay coarse facies and early death and also have an effect on one’s propensity to develop diabetes. Growth Retardation, Developmental Delay, Coarse Facies and Early Death is a rare syndrome characterized by retarted growth, coarse facial appearance, and early death. Affected individuals often times have shot digits, small heads, seizures, short necks, cleft palate, anteverted nostrils, recessed jaw, protruding tongue, and suffer early death. Anti-insulin antibody binds against insulin. Insulin decreases the amount of glucose in the blood by accelerating glycolysis and glycogen synthesis in the liver. Insulin is secreted by the pancreas. Defects in INS are the cause of familial hyperproinsulinemia, type 2 diabetes, and permanent neonatal diabetes mellitus. Familial hyperproinsulinemia is an autosomal dominant defect that is characterized by elevated levels of serum preinsulin-like material. Permanent neonatal diabetes mellitus is associated with the onset of hyperglycemia within the first 6 months of life that does not resolve over time. Permanent neonatal diabetes mellitus results in intrauterine growth retardation and low birth weight. Treatment with insulin helps children diagnosed with this extremely rare diabetic disorder.

 
Product Number Title Applications Host Clonality
AC15-0119 Anti-Creatine Kinase MM Antibody ELISA, WB, IHC, ICC, IF Goat Polyclonal
AC16-0039 Anti-NeuroD1 Antibody IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0049 Anti-FTO Antibody WB, IHC(F), ICC, IF, FC Rabbit Polyclonal
AC16-0039-01 Anti-NeuroD1 Antibody (AMCA) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-02 Anti-NeuroD1 Antibody (AP) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-03 Anti-NeuroD1 Antibody (APC) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-04 Anti-NeuroD1 Antibody (APC-Cy5.5) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-05 Anti-NeuroD1 Antibody (APC-Cy7) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-06 Anti-NeuroD1 Antibody (Avidin) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-07 Anti-NeuroD1 Antibody (Biotin) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-08 Anti-NeuroD1 Antibody (BPE) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)
AC16-0039-09 Anti-NeuroD1 Antibody (Cy3) IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (BC18-1.11EG)