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Developmental Biology Antibodies

Developmental biology is the study of the process by which organisms grow and develop. These developmental processes include cell growth, differentiation, and organogenesis. Cell growth refers to cell development and cell division or reproduction. Cell differentiation is the process where cells develop into specific cell types. This process is critical during embryonic development among other developmental stages in higher level organism development. Organogenesis is the process by which tissues and organs are developed from the extoderm, endoderm, and mesoderm germ layers in utero.

Anti-FOXC1 antibody binds against FOXC1. FOXC1 is a forkhead box protein that binds FREAC-3 and FREAC-4 to their sites on DNA. This process results in the bending of DNA at an 80-90 degree angle. FOXC1 is localized in the nucleus of a cell and expressed in all tissues and cell lines. Defects in FOXC1 are the cause of Axenfeld-Rieger syndrome type 3, iridogoniodysgenesis, and Peter’s anomaly. Axenfeld-Rieger syndrome type 3 is a disorder of the eye. Axenfeld-Rieger syndrome type 3 is an autosomal dominant disorder in which affected individuals often have abnormalities of the iris, pupil, and teeth in addition to a glaucoma (found in 50% of diagnosed individuals). Iridogoniodysgenesis is a hereditary ocular disease characterized by unusually dark irises and often times glaucoma. Peter’s anomaly is a very rare disorder which causes corneal opacity which effectively decreases the ability to see to the point of near or complete blindness. Anti-FLAP antibody binds against the target FLAP. FLAP (ALOX5AP) functions as a membrane anchor by anchoring ALOX5 to the membrane. FLAP is required for leukotriene biosynthesis because it binds to MK-886 which is a compound that will block leukotriene biosynthesis. FLAP is localized in the nucleus membrane, and the endoplasmic reticulum. Defects in FLAP may be one cause of susceptibility to ischemic stroke and susceptibility to myocardial infarction. Ischemic stroke occurs when blood supply to the brain is interrupted depriving the brain cells of vital oxygen. This disruption is due to a blocked or burst blood vessel in the brain. In ischemic stroke, the cause is a blood clot, wherein a hemorrhagic stroke is caused by a burst vessel. Myocardial infarction is a heart attack. Heart attacks result when the blood supply to a part of the heart is interrupted causing damage to the heart.

 
Product Number Title Applications Host Clonality
AC15-0116 Anti-TGF beta Antibody ELISA, WB, IHC, ICC, IF Chicken Polyclonal
AC15-0117 Anti-hCG Antibody ELISA, WB, IHC, ICC, IF Goat Polyclonal
AC16-0036 Anti-SOX17 Antibody ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0038 Anti-MyoD1 Antibody ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC1-C2H8)
AC16-0045 Anti-KLF4 Antibody ELISA, WB Rabbit Polyclonal
AC16-0046 Anti-Oct4 Antibody WB Rabbit Polyclonal
AC16-0063 Anti-Smoothelin Antibody WB, IHC(F), IHC(P), ICC, IF, FC, FUNC Mouse Monoclonal (R4A)
AC16-0036-01 Anti-SOX17 Antibody (AMCA) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-02 Anti-SOX17 Antibody (AP) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-03 Anti-SOX17 Antibody (APC) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-04 Anti-SOX17 Antibody (APC-Cy5.5) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
AC16-0036-05 Anti-SOX17 Antibody (APC-Cy7) ELISA, WB, IHC(F), IHC(P), IP Mouse Monoclonal (BC24-3.5CH)
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Category
  1. Embryogenesis (716)
  2. Lineage Determination (1016)
  3. Organogenesis (1316)
  4. Reproduction (674)
Application
  1. ChIP (46)
  2. EIA (46)
  3. ELISA (3079)
  4. FC (590)
  5. FUNC (12)
  6. ICC (665)
  7. IF (616)
  8. IHC (1030)
  9. IHC(F) (46)
  10. IHC(P) (59)
  11. IP (559)
  12. RIA (3)
  13. WB (2553)
Conjugate
  1. Alexa FluorÔö¼┬½ 488 (1)
  2. Alexa FluorÔö¼┬½ 647 (1)
  3. Alexa FluorÔö¼┬½ 700 (3)
  4. AMCA (144)
  5. AP (144)
  6. APC (152)
  7. APC-Cy5.5 (144)
  8. APC-Cy7 (144)
  9. Avidin (144)
  10. Biotin (149)
  11. BPE (144)
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  13. Cy5 (144)
  14. Cy5.5 (144)
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  20. PE (10)
  21. PE-Cy5 (144)
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  23. PE-Cy7 (144)
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  27. PerCP-Cy5.5 (144)
  28. PerCP-Cy™5.5 (3)
  29. Rhodamine (144)
  30. RPE (144)
  31. Streptavidin (144)
Clonality
  1. Monoclonal (1/24) (23)
  2. Monoclonal (104D2) (6)
  3. Monoclonal (3E2D10 + VWF635) (23)
  4. Monoclonal (4H11[APG]) (9)
  5. Monoclonal (581) (7)
  6. Monoclonal (66.4.C2; same as PN-15) (23)
  7. Monoclonal (67A4) (4)
  8. Monoclonal (AE-20) (23)
  9. Monoclonal (AFP-01) (1)
  10. Monoclonal (AFP-11) (1)
  11. Monoclonal (AL-01) (2)
  12. Monoclonal (BC1-C2H8) (23)
  13. Monoclonal (BC24-3.5CH) (23)
  14. Monoclonal (C31.3 + JC/70A) (23)
  15. Monoclonal (C31.3) (23)
  16. Monoclonal (C6/372) (23)
  17. Monoclonal (Ds-2) (1)
  18. Monoclonal (EM-04) (4)
  19. Monoclonal (Fn-3) (23)
  20. Monoclonal (HCGa/53) (23)
  21. Monoclonal (HCGb/54) (23)
  22. Monoclonal (Hs-14) (2)
  23. Monoclonal (Hs-8) (1)
  24. Monoclonal (IVA50) (1)
  25. Monoclonal (J2D10) (23)
  26. Monoclonal (M2-7C10 + M2-9E3 + T311 + HMB45) (23)
  27. Monoclonal (MEM-101A) (6)
  28. Monoclonal (MEM-188) (10)
  29. Monoclonal (MEM-61) (7)
  30. Monoclonal (MFG-06) (1)
  31. Monoclonal (mN1A) (2)
  32. Monoclonal (NF-09) (1)
  33. Monoclonal (OJ79c) (23)
  34. Monoclonal (QBEnd-10) (4)
  35. Monoclonal (QBEND-10) (23)
  36. Monoclonal (R4A) (23)
  37. Monoclonal (SPM123) (23)
  38. Monoclonal (SPM246) (23)
  39. Monoclonal (SPM406) (23)
  40. Monoclonal (SPM427) (23)
  41. Monoclonal (SPM539) (23)
  42. Monoclonal (SPM564) (23)
  43. Monoclonal (SPM576) (23)
  44. Monoclonal (VG76e) (23)
  45. Monoclonal (VI-01) (2)
  46. Monoclonal (VI-10) (1)
  47. Monoclonal (VI-RE/1) (2)
  48. Monoclonal (VWF635) (23)
  49. Monoclonal (zdc2) (23)
  50. Monoclonal (zdd2) (23)
  51. Polyclonal (2705)
Host Species
  1. Chicken (23)
  2. Goat (2618)
  3. Mouse (715)
  4. Rabbit (62)
  5. Rat (4)
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