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Dendrite Markers

Neurons are specialized cells of the nervous system designed to transmit chemical and electrical signals throughout the body. A biological marker is an indicator of a biological state. Often times it may be difficult to take biopsy or living tissue sample for medical diagnostics or scientific research purposes. Neuronal markers make it easier to look into the nervous system. Neuronal markers are present in the brain and peripheral nervous system and are indicative of certain neuronal diseases, statuses, or conditions. Neuronal markers are typically very effective diagnostic or prognostic tools in the treatment of sickness. These biomarkers can also be used to identify neural cells or detect expression details of certain types of molecules. Neuron markers sold by Abcore Inc. can be categorized into axon markers, dendrite markers, growth cone markers, soma markers, and synapse markers.

Anti-FMRP antibody binds against the target fragile X mental retardation protein. Fragile X mental retardation protein is localized in the cytoplasm of cells in the nucleus and nucleolus. FMRP is expressed in the highest levels in neurons, brain, testis, placenta, and lymphocytes but it is also expressed in epithelial tissues and in glial cells. Fragile X mental retardation protein is a translation repressor which binds to the mRNA cap which mediates translational repression and may also play a role in mRNA transport out of the nucleus into the cytoplasm. Defects in FMR1 are the cause of fragile X syndrome and premature ovarian failure syndrome type 1. Fragile X syndrome is a genetic disorder which affects the ordinary disposition of the X chromosome. The X chromosome is a sex chromosome present in both males and females (although females will have 2 copies of the X). The gene FMR1 (FMRP) can contain repeated segments. The more repeats the gene has, the more chances that the fragile areas of the X chromosome will contain defects. The proteins made by the FMR1 gene are required for proper brain growth. Females, having 2 X chromosomes, are less likely to be affected by one defective X, whereas males, having only 1 X chromosome, will become affected if their X chromosome is defective. Affected individuals suffer from delayed motor development, mental development, and social development. Physical signs include flat feet, low muscle tone, large forehead, and larger body size. Premature ovarian failure syndrome is also known as pre-mature or early menopause.

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11-528 Anti-LST1 Antibody WB, ICC, IP Mouse Monoclonal (LST1/02)
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