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Cytokines

Cytokines are cell signaling molecules composed of protein that are secreted by many different bodily cells. The cytokines can interact with the cells of the immune system in order to regulate the body's response to disease and infection. They also regulate various inflammatory responses. There are many different types of cytokines including colony stimulating factors, growth and differentiation factors, and immunoregulatory and proinflammatory cytokines. Simplified, the mechanism of action commences when the cytokine is released into circulation or directly into a tissue. The cytokines then target their specific target immune cells and bind to them. The formation of this complex can trigger or stimulate an immune response by the bound immune cell. When cytokines are overproduced and over-secreted, disease results. Anti-cytokine antibodies can bind against cytokines and change their course of action. These antibodies are useful in treating overproduced or inappropriately acting cytokine responses in hopes to decrease the inflammatory diseases that they cause.

Anti-IRAK4 Antibody binds against interleukin 1 receptor associated kinase 4. IRAK4 triggers intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization and phosphorylates IRAK1. Defects in IRAK4 cause recurrent isolated invasive pneumococcal disease type 1 and IRAK4 deficiency. Recurrent isolated invasive pneumococcal disease type 1 occurs when the individual has two episodes of IPD occurring at least one month apart. IPD, or invasive pneumococcal disease, is an infection caused by streptococcus pneumonia which results in pneumonia, sepsis, ear infection, and bacterial meningitis. IRAK4 deficiency is very rare inherited disorder of the immune system which leads to recurrent infections by pyogenic (puss producing) bacteria. Anti-SOCS3 antibody binds against the target SOCS3. SOCS3 is expressed in the heart, placenta, skeletal muscle, peripheral blood leukocytes, lung, and kidney. It is a negative regulator of cytokines. Defects in SOCS3 are implicated in atopic dermatitis. Atopic dermatitis is a chronic skin disorder that involves scaly and itchy rashes. Symptoms include blisters, discharge, raw skin, redness, and inflammation.

 
Product Number Title Applications Host Clonality
AC16-0034 Anti-IL12A Antibody ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0041 Anti-Visfatin Antibody ELISA, WB, IHC(F), IHC(P) Rat Monoclonal (14A5)
AC16-0048 Anti-TNF Receptor I Antibody ELISA, WB, IHC(P), FC Rabbit Polyclonal
AC16-0059 Anti-TNF Receptor I Antibody ELISA, IHC(F), ICC, IF, FC Mouse Monoclonal (htr9)
AC16-0060 Anti-TNF Receptor I Antibody WB, IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (utr1)
AC16-0034-01 Anti-IL12A Antibody (AMCA) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0034-02 Anti-IL12A Antibody (AP) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0034-03 Anti-IL12A Antibody (APC) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0034-04 Anti-IL12A Antibody (APC-Cy5.5) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0034-05 Anti-IL12A Antibody (APC-Cy7) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0034-06 Anti-IL12A Antibody (Avidin) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)
AC16-0034-07 Anti-IL12A Antibody (Biotin) ELISA, WB, IHC(F), IHC(P), IP Rat Monoclonal (C17.8)