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Chromosome Structure

A chromosome is a condensed, structured body of arranged genetic material. The amount of genetic material in the nucleus of cells is enormous compared to the amount of space in which it is contained. For this reason, the genetic material must be condensed and contained while still easily accessible. Deoxyribonucleic acid, or DNA, can be either a long linear chain or circular plasmid. In humans, DNA exists as a linear chain combined with histone proteins and tightly wound together to form the chromosome itself. Chromosome structure of eukaryotes consists of two chromatids attached in the center by a centromere. Looking closer at the chromatids, a tightly wound DNA strand organized around histone proteins forms a nucleosome. These nucleosomes are further wound and stacked with the connected DNA in order to form the chromatin fiber. Prokaryotic chromosomes exist in the cells cytoplasm in an area called the nucleoid. Typically, bacteria will have one circular "chromosome" called a plasmid. Chromosome structure antibodies are useful in many areas of research and laboratory applications.

Anti-SET antibody binds against a target protein SET. SET is involved in apoptosis, transcription, nucleosome assembly, and histone binding. Both isoforms 1 and 2 of SET protein inhibit protein phosphatase and acetylation of histones and nucleosomes. The SET translocation protein mainly targets histone H4, and belongs to the nucleosome assembly protein (NAP) family. Anti-SET antibody functions in the cytoplasm, endoplasmic reticulum, and nucleus. SET is widely expressed in many tissues throughout the body. A chromosomal error involving the gene that codes for SET is sometimes responsible for causing acute undifferentiated leukemia. Acute undifferentiated leukemia, or stem cell leukemia, is characterized by acute myelogenous leukemia cells which are too immature to be classified. Anti-Tankyrase antibody binds against the enzyme tankyrase. Tankyrase is involved in vesicle transport and subcellular distribution of vesicles as well as telomere length regulation. Tankyrase is expressed in many tissues in the body but has very high expression levels in the testis. TANK 1 antibody binds against targets in the cytoplasm (golgi apparatus), chromosome (centromere), nucleus (nuclear pore complex), and chromosome (telomere).

 
Product Number Title Applications Host Clonality
AC21-2632 Anti-Telomerase Reverse Transcriptase Antibody ELISA, WB Goat Polyclonal
AC21-2802 Anti-MKRN1 Antibody ELISA, WB Goat Polyclonal
AC21-0010-01 Anti-Tankyrase 2 Antibody (AMCA) WB Goat Polyclonal
AC21-0010-02 Anti-Tankyrase 2 Antibody (AP) WB Goat Polyclonal
AC21-0010-03 Anti-Tankyrase 2 Antibody (APC) WB Goat Polyclonal
AC21-0010-04 Anti-Tankyrase 2 Antibody (APC-Cy5.5) WB Goat Polyclonal
AC21-0010-05 Anti-Tankyrase 2 Antibody (APC-Cy7) WB Goat Polyclonal
AC21-0010-06 Anti-Tankyrase 2 Antibody (Avidin) WB Goat Polyclonal
AC21-0010-07 Anti-Tankyrase 2 Antibody (Biotin) WB Goat Polyclonal
AC21-0010-08 Anti-Tankyrase 2 Antibody (BPE) WB Goat Polyclonal
AC21-0010-09 Anti-Tankyrase 2 Antibody (Cy3) WB Goat Polyclonal
AC21-0010-10 Anti-Tankyrase 2 Antibody (Cy5) WB Goat Polyclonal