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Chromatin Remodeling

Chromatin is the structure formed between DNA and proteins assembled in the cell's nucleus. The nucleosome is the basic unit of chromatin and is highly condensed making the individual genetic material or genes on the DNA hidden or inaccessible by certain biological molecules. Chromatin remodeling involves enzymes that affect DNA transcription. Chromatin remodeling enzymes essentially work to make the condensed chromatin accessible for transcription factors, DNA replication, recombination, and repair. This remodeling occurs with the assistance of histone modification enzymes and ATP-dependent chromatin remodeling complexes. In addition to regulating gene expression, chromatin remodeling also plays an epigenetic role in DNA replication, DNA repair, apoptosis, and chromosome segregation.

MeCP2 is a protein that binds to DNA and mediates the repression of transcription through involvement with histone deacetylase. Anti- MeCP2 antibody shows affinity to bind to MeCP2 protein. Defects in this protein are the cause of both Rett syndrome and Angelman syndrome (AS). Rett syndrome is a neurologic disorder which causes mental retardation, loss of speech, and seizures. AS is known as happy puppet syndrome and is similar to Rett syndrome. Autism X- linked type 3 is also thought to be caused by defects in MeCP2. The increased dosage of MeCP2 due to multiple copies of the gene (gene duplication) is thought to be the culprit in causing the mental retardation phenotypes. Anti- FOXP3 antibody detects a section of human FOXP3 protein. The FOXP3 protein is a transcription factor that controls certain immune responses and is thought to play a role in diabetes, infections (autoimmune and immunodeficiency), and anemia.

 
Product Number Title Applications Host Clonality
AC21-2883 Anti-WDR9 Antibody ELISA Goat Polyclonal
AC21-2884 Anti-WDR9 Antibody ELISA Goat Polyclonal
AC21-0064-01 Anti-SET Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0064-02 Anti-SET Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0064-03 Anti-SET Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0064-04 Anti-SET Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal
AC21-0064-05 Anti-SET Antibody (APC-Cy7) ELISA, WB Goat Polyclonal
AC21-0064-06 Anti-SET Antibody (Avidin) ELISA, WB Goat Polyclonal
AC21-0064-07 Anti-SET Antibody (Biotin) ELISA, WB Goat Polyclonal
AC21-0064-08 Anti-SET Antibody (BPE) ELISA, WB Goat Polyclonal
AC21-0064-09 Anti-SET Antibody (Cy3) ELISA, WB Goat Polyclonal
AC21-0064-10 Anti-SET Antibody (Cy5) ELISA, WB Goat Polyclonal