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Chromatin Modifying Enzymes

Chromatin is the structure formed between DNA and proteins assembled in the cell's nucleus. The nucleosome, the basic unit of chromatin, is highly condensed making the individual genetic material or genes on the DNA hidden or inaccessible by certain biological molecules. The DNA is wound around histone proteins. Chromatin modification involves enzymes that affect DNA transcription. Chromatin modifying enzymes essentially work to make the condensed chromatin accessible for transcription factors, DNA replication, recombination, and repair. There are many different surfaces to nucleosomes which provide many different binding sites for chromatin modifying enzymes. There are at least eight different classes of modifiers which have been characterized based on site and mechanism of action. These chromatin modifying enzymes have the potential to influence many fundamental biological processes of which some may be epigenetically inherited.

MeCP2 is a protein that binds to DNA and mediates the repression of transcription through involvement with histone deacetylase. Anti- MeCP2 antibody shows affinity to bind to MeCP2 protein. Defects in this protein are the cause of both Rett syndrome and Angelman syndrome (AS). Rett syndrome is a neurologic disorder which causes mental retardation, loss of speech, and seizures. AS is known as happy puppet syndrome and is similar to Rett syndrome. Autism X- linked type 3 is also thought to be caused by defects in MeCP2. The increased dosage of MeCP2 due to multiple copies of the gene (gene duplication) is thought to be the culprit in causing the mental retardation phenotypes. Anti- FOXP3 antibody detects a section of human FOXP3 protein. The FOXP3 protein is a transcription factor that controls certain immune responses and is thought to play a role in diabetes, infections (autoimmune and immunodeficiency), and anemia.

 
Product Number Title Applications Host Clonality
AC21-2662 Anti-HDAC1 Antibody ELISA, WB Goat Polyclonal
AC21-2682 Anti-PRDM16 Antibody ELISA, WB Goat Polyclonal
AC21-2683 Anti-PRMT3 Antibody ELISA, WB Goat Polyclonal
AC21-2684 Anti-PRMT2 Antibody ELISA, WB Goat Polyclonal
AC21-2685 Anti-PRMT6 Antibody ELISA, WB Goat Polyclonal
AC21-2686 Anti-PRMT7 Antibody ELISA, WB Goat Polyclonal
AC21-2804 Anti-SIRT1 Antibody ELISA, WB Goat Polyclonal
AC21-2983 Anti-KAT13D / CLOCK Antibody ELISA, WB Goat Polyclonal
AC21-0034-01 Anti-MTR Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0034-02 Anti-MTR Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0034-03 Anti-MTR Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0034-04 Anti-MTR Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal