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Chromatin Binding Proteins

The nucleus of the cell is the area in which DNA and other nuclear proteins are housed. Chromatin is the structure formed between DNA and proteins assembled in the cell's nucleus. During cell division, the mass of material called chromatin (including histone proteins) can condense to form structures called chromosomes. The nucleosome is the basic unit of DNA packaging and is highly condensed making the individual genetic material or genes on the DNA hidden or inaccessible by certain biological molecules. Chromatin remodeling and binding involves enzymes and proteins that affect DNA transcription. Chromatin binding proteins, or DNA binding proteins, contain binding domains which are attracted to certain segments of DNA. These proteins are able to affect many aspects of DNA transcription and can be naturally occurring in cells or composed extracellular molecules. Examples of DNA binding proteins include the zinc finger and the helix-turn-helix.

Anti-PARK7/DJ1 antibody binds against the target protein Parkinson protein 7. Park 7 is encoded by the gene PARK7 and protects cells against oxidative stress and cell death. Park 7 has a number of very important functions which include eliminating hydrogen peroxide from cells, regulating mitochondrial morphology and function, destroying dysfunctional mitochondria, and regulating astrocyte inflammatory responses. Park7 is localized in the nucleus, mitochondria, and cytoplasm of cells. This protein is highly expressed in the pancreas, kidney, skeletal muscle, liver, testis, and heart. Defects in PARK7 are the cause of early onset Parkinson's disease. Anti-CECR2 antibody binds against the target CECR2. CECR2 is a bromodomain found in chromatin associated proteins. Bromodomains interact with acetylated lysine and contain several mammalian T-cell surface antigen CD2 proteins as well as homologous African swine fever virus sequences. Defects in CECR2 are implicated in cat eye syndrome. Cat eye syndrome is a developmental disorder caused by a defect on chromosome 22. Affected individuals have impaired mental function, disorders of the heart and kidneys, and malformations of the eye (including iris and retina issues).

Product Number Title Applications Host Clonality
AC21-2633 Anti-PCBP3 Antibody ELISA Goat Polyclonal
AC21-2634 Anti-KLF13 Antibody ELISA, WB Goat Polyclonal
AC21-2660 Anti-ZBT24 Antibody ELISA, WB Goat Polyclonal
AC21-2687 Anti-LSM2 Antibody ELISA, WB Goat Polyclonal
AC21-2688 Anti-LSM3 Antibody ELISA Goat Polyclonal
AC21-2689 Anti-LSM5 Antibody ELISA Goat Polyclonal
AC21-2690 Anti-LSM6 Antibody ELISA Goat Polyclonal
AC21-2709 Anti-Fibrillarin Antibody ELISA, WB Goat Polyclonal
AC21-2710 Anti-Fibrillarin Antibody ELISA, WB Goat Polyclonal
AC21-2715 Anti-PCNA Antibody ELISA, WB Goat Polyclonal
AC21-2716 Anti-PCNA Antibody ELISA, WB Goat Polyclonal
AC21-2799 Anti-UHRF1 Antibody ELISA, WB Goat Polyclonal