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Chemokines

Chemokines are small cytokine proteins secreted by cells. They have the ability to cause nearby responsive cells to become chemotaxic. Chemokines are approximately 8-10 kilodaltons in size and are composed of four cysteine molecules and amino acids that fold to become 3-dimensional structures. The major role of chemokines is to guide the migration of cells. They do this by acting as a chemoattractant and guiding the migration of cells. The migrating cells follow the increasing chemokine concentration towards the source of the chemokine. There are four groups of chemokines categorized by the spacing on their first two cysteine residues. These groups are CC chemokines, CXC chemochines, C chemokiens, and CX3C chemokines. Chemokine receptors are G protein coupled transmembrane receptors. They are found on the surface of leukocytes. These chemokine receptors are useful in signal transduction byway of a binding ligand. They bind to many different G protein receptors and cause conformational changes that trigger intracellular pathways involved in cell movement and activation. Chemokines are useful in immune responses. They are produced in acute and chronic inflammation to mobilize and activate white blood cells. Defects in chemokine pathways, or ill regulation, can contribute to inflammatory diseases and even cancer. In graft rejections, for instance, chemokines are implicated in the attraction of leukocytes to allografts which is essential for graft rejection.

Anti-lymphotactin antibody binds against the target lymphotactin. Lymphotactin is secreted by cells and expressed at very high levels in the spleen, and lower levels in the peripheral leukocytes, lung, colon, and small intestine. Lymphotactin is a chemotactic activity protein for lymphocytes but not for monocytes or neutrophils. Lymphotactin is also a key regulator of lymphocyte motility and adhesiveness during acute allograft rejection. Anti-DARC antibody binds against the target duffy antigen/chemokine receptor. The duffy blood group chemokine receptor is localized on the cell membrane and found in adult kidney, spleen, bone marrow, and fetal liver cells. DARC is a receptor for many chemokines as well as human malaria parasites plasmodium vivax and plasmodium knowlesi.

 
Product Number Title Applications Host Clonality
AC21-2818 Anti-Eotaxin Antibody ELISA Goat Polyclonal
AC21-0781-01 Anti-DARC Antibody (AMCA) ELISA, WB, IHC, FC Goat Polyclonal
AC21-0781-02 Anti-DARC Antibody (AP) ELISA, WB, IHC, FC Goat Polyclonal
AC21-0781-03 Anti-DARC Antibody (APC) ELISA, WB, IHC, FC Goat Polyclonal
AC21-0781-04 Anti-DARC Antibody (APC-Cy5.5) ELISA, WB, IHC, FC Goat Polyclonal
AC21-0781-05 Anti-DARC Antibody (APC-Cy7) ELISA, WB, IHC, FC Goat Polyclonal
AC21-0781-06 Anti-DARC Antibody (Avidin) ELISA, WB, IHC, FC Goat Polyclonal
AC21-0781-07 Anti-DARC Antibody (Biotin) ELISA, WB, IHC, FC Goat Polyclonal
AC21-0781-08 Anti-DARC Antibody (BPE) ELISA, WB, IHC, FC Goat Polyclonal
AC21-0781-09 Anti-DARC Antibody (Cy3) ELISA, WB, IHC, FC Goat Polyclonal
AC21-0781-10 Anti-DARC Antibody (Cy5) ELISA, WB, IHC, FC Goat Polyclonal
AC21-0781-11 Anti-DARC Antibody (Cy5.5) ELISA, WB, IHC, FC Goat Polyclonal