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Cell Cycle Inhibitors

The many processes that control the cell cycle are highly regulated and complex. Cell cycle signaling involves many different pathways that control everything from apoptosis, growth, gene regulation, immune signaling, neurotransmission, and basic cell cycle processes. Cell division occurs primarily in the nucleus where the DNA is housed. These processes include replication of DNA and mitosis or cell division. The replication of DNA has 3 distinct phases in which cells will increase in size, DNA is duplicated, and a cell will continue to grow larger until it ultimately divides into two. These cell cycle phases are followed by the process of mitosis and an effective break or period of rest from division. Cell cycle inhibitors are involved in the cell division cycle as well and can interact with all phases of the cell cycle. Cell cycle inhibitors ultimately prevent the progression of the cell cycle. Natural and artificial cell cycle inhibitors exist. Synthetic inhibitors can be useful for the arrest of the cell cycle and therefore are useful as antineoplastic and anticancer agents.

Anti-JAK2 antibody binds against the target JAK2. JAK2 is localized in the endomembrane system and in the nucleus. JAK2 is expressed in the blood, bone marrow, and lymph nodes. JAK2 is a non-receptor tyrosine kinase involved in many processes such as cell cycle progression, apoptosis, mitotic recombination, genetic instability, and histone modification. Defects in JAK2 are the cause of Budd-Chiari syndrome, polycythemia vera, essential thrombocythemia, and myelofibrosis. Budd-Chiari syndrome, or hepatic vein obstruction, prevents blood from flowing out of the liver and back to the heart. This causes liver damage. Symptoms include jaundice, bloody vomit, and abdominal pain. Polycythemia vera is a bone marrow disorder characterized by the overproduction of red blood cells. Symptoms include dizziness, headache, itchiness, and red skin spots. Essential or primary thrombocythemia is a disorder characterized by too many platelets being produced by the bone marrow. Symptoms include easy bruising, bloody stools, and numbness of hands or feet. Myelofibrosis is a disorder of the bone marrow in which the marrow is replaced by scar tissue. Symptoms include bone pain, bruising, and shortness of breath. Anti-axin 1 antibody binds against the target axin1. Axin 1 is localized in the cytoplasm, nucleus, and cell membrane of cells and ubiquitously expressed in all tissues. Defects in AXIN1 are involved in hepatocellular carcinoma and caudal duplication anomaly. Hepatocellular carcinoma is the most common form of liver cancer, although overall a very rare form of cancer here in the U.S.A. Symptoms include abdominal pain, enlarged abdomen, and jaundice.

 
Product Number Title Applications Host Clonality
AC16-0045 Anti-KLF4 Antibody ELISA, WB Rabbit Polyclonal
AC16-0047 Anti-p53 Antibody ELISA, WB, IHC(F), IHC(P) Rabbit Polyclonal
AC16-0045-01 Anti-KLF4 Antibody (AMCA) ELISA, WB Rabbit Polyclonal
AC16-0045-02 Anti-KLF4 Antibody (AP) ELISA, WB Rabbit Polyclonal
AC16-0045-03 Anti-KLF4 Antibody (APC) ELISA, WB Rabbit Polyclonal
AC16-0045-04 Anti-KLF4 Antibody (APC-Cy5.5) ELISA, WB Rabbit Polyclonal
AC16-0045-05 Anti-KLF4 Antibody (APC-Cy7) ELISA, WB Rabbit Polyclonal
AC16-0045-06 Anti-KLF4 Antibody (Avidin) ELISA, WB Rabbit Polyclonal
AC16-0045-07 Anti-KLF4 Antibody (Biotin) ELISA, WB Rabbit Polyclonal
AC16-0045-08 Anti-KLF4 Antibody (BPE) ELISA, WB Rabbit Polyclonal
AC16-0045-09 Anti-KLF4 Antibody (Cy3) ELISA, WB Rabbit Polyclonal
AC16-0045-10 Anti-KLF4 Antibody (Cy5) ELISA, WB Rabbit Polyclonal