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Cell Adhesion

Cell Adhesion molecules are very important for structural integrity, external sensing, migration, regulation of transport, and communication. Cell adhesion refers to the affinity for a cell to attach to another cell, an extracellular surface, or the cell matrix. Cell adhesion molecules include integrins, selectins, and immunoglobulin cadherens. Integrins assist primarily in cell to matrix adhesions but are present in some cell to cell adhesions. Selectins are circulating and endothelial cells that are on the move, and immunoglobulin cadherens play important roles in immune responses.

Anti-claudin 14 antibody binds against the target claudin 14. Claudin 14 is localized in the cell junction and on the cellular membrane and expressed in the liver, kidney, and the ear. It plays a role in tight junction specific obliteration of intercellular space through a calcium independent cell adhesion activity. Defects in CLDN14 are the cause of deafness autosomal recessive type 29. Deafness autosomal recessive type 29 is a form of non-syndromic sensorineural hearing loss. Anti-fibulin 5 antibody binds against the target fibulin 5. Fibulin 5 is secreted by cells and expressed in the heart, ovary, colon, kidney, pancreas, testis, lung, and placenta. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Defects in FBLN5 are the cause of autosomal dominant cutis laxa and age-related macular degeneration type 3. Cutis laxa is a connective tissue disorder characterized by sagging skin that is not elastic and hangs in loose folds. Macular degeneration is a disorder of the eye resulting in loss of vision in the center of the visual field.

 
3 products match Monoclonal (3B2/TA8)

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Product Number Title Applications Host Clonality
1P-658 Anti-CD99 Antibody (PE) FC Mouse Monoclonal (3B2/TA8)
11-658 Anti-CD99 Antibody FC Mouse Monoclonal (3B2/TA8)
1F-658 Anti-CD99 Antibody (FITC) FC Mouse Monoclonal (3B2/TA8)
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  1. Remove This Item Clonality: Monoclonal (3B2/TA8)
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