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CD and MHC Antibodies

Cluster of differentiation and major histocompatibility antibodies are useful in many aspects of research specifically immunology. The major histocompatibility complex or MHC lives on the surface of the cell. MHC represents antigens that are invaluable in immune responses. Cluster of differentiation is useful in categorizing antibodies on the surface of cells, like the major histocompatibility antibodies. More specifically, CD antibodies will categorize similar types of surface molecules binding to the same types on ligands. MHC antibodies bind against cells in the body involved in immune response just as cluster of differentiation antibodies bind against ligands on the surface of immune system cells like what blood cells.

Cluster of differentiation is the process used for identifying and inspecting the surface molecules on white blood cells. This classification refers to monoclonal antibodies that bind to antigens on surface molecules of immune system cells. With the arrival of monoclonal antibody technology, the classification of cell surface antigens was transformed. There are numerous and basically unlimited antibodies that can bind to similar or identical antigens on the surface of white blood cells. Because of this, cluster of differentiation was needed to determine which act similarly and thus can be clustered in groups of similar assimilation. The antibodies ability to react with human cells or human cell proteins was analyzed and assigned to cluster groups. CD antibodies are thus antibodies that are different in background and source but can bind to identical antigens and thus remain part of the same cluster group. These antigens act in a vast array of ways that are important to immune system responses of living organisms.

The major histocompatibility complex is an area in which intracellular antigens are represented on the outer surface of the cell. MHC genes code for these specific proteins. These antigens are responsible for major immune responses such as the recognition of foreign substances. These proteins are found in all upper level vertebrates. There are 3 major classes of histocompatibility complexes: Class I, Class II and Class III. The molecules in class I and II belong to a group called immunoglobulin supergenes which is comprised of immunoglobulins and T- Cell receptors. Class I MHC molecules are found widely across all cell membranes. Class II molecules are only found in immune system cells such as macrophages and lymphocytes. The Class III MHC molecules include only compliment components. In humans, the MH complex is also known as the human leukocyte antigen or HLA system. The genetic code for these genes is found on the human chromosome 6. The genes for MHC proteins are widely varied in the human population and thus allows for many different tissue types. This is important when studying organ and tissue transplants. Antigens bind to MHC antibodies which can affect the response of the immune system and are quite commonly responsible for post-transplant rejections of organs and tissues.

 
Product Number Title Applications Host Clonality
AC21-2643 Anti-HA1 Antibody ELISA Goat Polyclonal
AC21-2643-01 Anti-HA1 Antibody (AMCA) ELISA Goat Polyclonal
AC21-2643-02 Anti-HA1 Antibody (AP) ELISA Goat Polyclonal
AC21-2643-03 Anti-HA1 Antibody (APC) ELISA Goat Polyclonal
AC21-2643-04 Anti-HA1 Antibody (APC-Cy5.5) ELISA Goat Polyclonal
AC21-2643-05 Anti-HA1 Antibody (APC-Cy7) ELISA Goat Polyclonal
AC21-2643-06 Anti-HA1 Antibody (Avidin) ELISA Goat Polyclonal
AC21-2643-07 Anti-HA1 Antibody (Biotin) ELISA Goat Polyclonal
AC21-2643-08 Anti-HA1 Antibody (BPE) ELISA Goat Polyclonal
AC21-2643-09 Anti-HA1 Antibody (Cy3) ELISA Goat Polyclonal
AC21-2643-10 Anti-HA1 Antibody (Cy5) ELISA Goat Polyclonal
AC21-2643-11 Anti-HA1 Antibody (Cy5.5) ELISA Goat Polyclonal
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  1. CD Antibodies (861)
  2. MHC Antibodies (346)
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  239. Polyclonal (25)
Host Species
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