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Caspases

Caspases are also known as the executioners of apoptosis. Apoptosis is the process by which cells die a pre-programmed cell death or PCD. The process is facilitated by processes within the cell using certain biochemicals that lead to changes in cell morphology and eventually leads to the cell dying. This is a natural process in the cell cycle and is necessary to maintain proper alignments of organ and organelle structure. Defects in the apoptosis of cells can lead to diseases such as cancer. Each cell must die in order to make room for fresh replacements. Apoptosis is essentially induction of cell suicide. Apoptosis can be triggered by internal or external signals like etoposide (a cytotoxic agent), DNA damage, growth factor withdrawal, toxic chemicals, and irradiation. Once apoptosis is committed, or triggered, execution with the help of caspases occurs. Caspases are enzymes which are typically dormant and must be activated. The activation of caspases results in nuclear, plasma-membrane, and mitochondrial changes. Inappropriate inhibition of caspases can occur by members of the CrmA, Bcl-2, and p35 family members. This inappropriate inhibition often leads to cancer or other disorders.

The anti-CARD15 antibody binds against the peptide CARD15. CARD15 confers responsiveness to intracellular bacterial lipopolysaccharides (LPS) and induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK-gamma. CARD15 protein is located in the cytoplasm of monocytes. Defects in CARD2 are the cause of Blau syndrome, sarcoidosis early-onset, and inflammatory bowel disease type 1. Blau syndrome and early onset sarcoidosis are dominant genetic disorders characterized by arthritis and skin granulomas (tumors or papules). Blau syndrome and early onset sarcoidosis are inflammatory diseases characterized by granulomas on the lungs, lymph nodes, skin, eyes, and liver. Inflammatory bowel disease can sometimes accompany a diagnosis of early onset sarcoidosis or Blau syndrome. Inflammatory bowel disease is characterized by abdominal pain, diarrhea, rectal bleeding, and severe internal cramps. Anti-Bcl-2 antibody binds against bcl-2. Bcl-2 suppresses apoptosis in many different cells and tissues. Bcl2 is located on the mitochondrion outer membrane, the nuclear membrane, and the endoplasmic reticulum membrane. Defects in BCL2 are thought to cause lymphatic leukemia, no-hodgkin lymphoma, and other types of cancers. Lymphatic leukemia is a progressive malignant disease of the blood forming tissues and organs including the bone marrow. The disease is characterized by distorted production and development of leukocytes and their precursors in the bone marrow and circulating blood.

 
Product Number Title Applications Host Clonality
AC21-2665 Anti-NLRP10 Antibody ELISA, WB, IF Goat Polyclonal
AC21-2723 Anti-Caspase 12 Antibody ELISA, WB Goat Polyclonal
AC21-2951 Anti-TMS1 Antibody ELISA Goat Polyclonal
AC21-2952 Anti-TMS1 Antibody ELISA, WB Goat Polyclonal
AC21-2981 Anti-Caspase 6 Antibody ELISA, WB Goat Polyclonal
AC21-2982 Anti-Caspase 6 Antibody ELISA, WB Goat Polyclonal
AC21-0027-01 Anti-FEM 1C Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0027-02 Anti-FEM 1C Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0027-03 Anti-FEM 1C Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0027-04 Anti-FEM 1C Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal
AC21-0027-05 Anti-FEM 1C Antibody (APC-Cy7) ELISA, WB Goat Polyclonal
AC21-0027-06 Anti-FEM 1C Antibody (Avidin) ELISA, WB Goat Polyclonal