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Cardiovascular Markers

The circulatory system is the organ system that assists in the passing of nutrients, hormones, and other molecules to and from cells in the body. The cardiovascular system is part of the circulatory system and distributes blood throughout an organism. The main components of the cardiovascular system are the heart, blood, and blood vessels. The hearts of vertebrates are composed of cardiac muscle and connective tissue. The human heart is composed of 4 chambers, the right atrium, the left atrium, the right ventricle, and the left ventricle. Fish also have a four chambered heart, consisting of a sinus venosus, atrium, ventricle, and conus arteriousus (with all 4 chambers arranged linearly). The crustacean heart has one large chamber and functions within an open circulatory system. Cardiovascular disease is an abnormal function of the heart and/or blood vessels. It is a category of disease that includes coronary heart disease (heart attacks), cerebrovascular disease (stroke), blood pressure problems, peripheral artery disease, rheumatic heart disease, congenital heart disease, and heart failure. Heart disease is the leading cause of human deaths across the world. There are many forms of heart disease and many can be prevented by healthy lifestyle choices. Other causes include atherosclerosis (buildup of fatty plaques in arteries), heart defects, and microorganisms. Heart failure occurs when the heart cannot continue to supply the necessary oxygenated blood to the body. Heart attacks occur when coronary arteries build up with blood clots which completely or partially block the blood flow. A stroke occurs when arteries in the brain are narrowed or blocked by a clot or plaque. Aneurysms occur in other parts of the body, apart from the brain and heart, and are also due to blocked blood flow. Peripheral artery disease, or PAD, occurs when the extremities (legs, hands, etc) do not get enough blood flow. Sudden cardiac arrest also occurs and is somewhat unexpected. Tests for diagnostics include bloodwork, chest X-rays, electrocardiogram (ECG), echocardiogram, certain types of scans, and even heart biopsy. Lifestyle changes, including eating a healthy diet, refraining from drinking and smoking, and getting plenty of exercise, have shown to reverse of treat certain types of heart disease. Other treatment options include prescription medication and surgery.

Anti-alpha smooth muscle actin antibody binds against the target alpha smooth muscle actin. Actins are globular proteins that are the main framework of the thin filaments of muscle fibers. Actins are highly conserved proteins that are involved in many types of cell mobility. Alpha smooth muscle actin is an isoform of the typical smooth muscle cells. This actin is localized in the cytoplasm and the cytoskeleton. Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6. Familial thoracic aortic aneurysm is an autosomal dominant form of large arterial disorder. The disease presents with a progressive breakdown of collagen, elastin, and smooth muscle in the wall of an artery, specifically the aorta. This causes the thoracic aorta to permanently dilate. Anti-calponin antibody binds against calponin. Calponin functions as a thin-filament protein regulator/modulator of smooth muscle contraction. Calponin can bind to actin and inhibit the actomyosin Mg-ATPase activity. Actomyosin Mg-ATPase is involved in cardioprotection by maintaining intracellular calcium levels in ventricular myocytes that require ATP.

 
Product Number Title Applications Host Clonality
AC16-0037 Anti-CD31 Antibody WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (BC16-6.4EF)
AC16-0061 Anti-CD31 Antibody ELISA, WB, IHC(F), ICC, IF, FC, ELISAM Rat Monoclonal (ER-MP12)
AC16-0063 Anti-Smoothelin Antibody WB, IHC(F), IHC(P), ICC, IF, FC, FUNC Mouse Monoclonal (R4A)
AC16-0037-01 Anti-CD31 Antibody (AMCA) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (BC16-6.4EF)
AC16-0037-02 Anti-CD31 Antibody (AP) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (BC16-6.4EF)
AC16-0037-03 Anti-CD31 Antibody (APC) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (BC16-6.4EF)
AC16-0037-04 Anti-CD31 Antibody (APC-Cy5.5) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (BC16-6.4EF)
AC16-0037-05 Anti-CD31 Antibody (APC-Cy7) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (BC16-6.4EF)
AC16-0037-06 Anti-CD31 Antibody (Avidin) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (BC16-6.4EF)
AC16-0037-07 Anti-CD31 Antibody (Biotin) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (BC16-6.4EF)
AC16-0037-08 Anti-CD31 Antibody (BPE) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (BC16-6.4EF)
AC16-0037-09 Anti-CD31 Antibody (Cy3) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (BC16-6.4EF)