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Carbohydrate Metabolism

Carbohydrate metabolism is the overall process of digesting and using for energy carbohydrates like polysaccharide starches and simple sugars like glucose, fructose, and galactose. The metabolism of carbohydrates is catalyzed by many useful enzymes in different biological pathways like glycogenesis/glycogenolysis, glycolysis/gluconeogenesis, and the lactic acid and citric acid cycles. These processes are catalyzed by many useful enzymes like acetyl coenzyme A, sulfatase, and glycosyltransferase. Larger carbohydrate molecules are first broken down into their smaller constituents during digestion. Animals and fungi use the food they eat as a source of carbohydrates, while plants can synthesize carbohydrates from gases in the atmosphere along with sunlight in the process called photosynthesis. Carbohydrates are made from carbon, oxygen, and hydrogen molecules. Human diseases of carbohydrate metabolism include diabetes, lactose intolerance, fructose intolerance, galactosemia, and glycogen storage disease.

Anti-PCK1 antibody catalyzes the conversion of oxaloacetate to phosphoenolypyruvate. This is a rate limiting step in the carbohydrate metabolic pathway that produces glucose from lactate in the citric acid cycle. PCK1 is localized in the cytoplasm and is present in the liver, kidney, and adipocytes. Defects in PCK1 are the cause of cytosolic phosphoenolpyruvate carboxykinase deficiency (cytosolic PEPCK deficiency). Individuals suffering from cytosolic phosphoenolpyruvate carboxykinase deficiency have impaired glucogenesis. Cytosolic phosphoenolpyruvate carboxykinase deficiency is an extremely rare autosomal recessive disorder having only about 10 cases ever reported. Anti-Glucose Transporter GLUT4 antibody binds against the glucose transporter GLUT4. GLUT4 is an insulin regulated facilitative glucose transporter. This glucose transporter is localized in the endomembrane system in the perinuclear region of the cytoplasm and is expressed in skeletal and cardiac muscles as well as brown and white fat. Defects in SLC2A4 may cause noninsulin-dependent diabetes mellitus. Noninsulin-dependent diabetes mellitus is mild form of diabetes that develops gradually in adults and can be precipitated by obesity, stress, or other factors.

 
Product Number Title Applications Host Clonality
AC16-0010 Anti-GAPDH Antibody WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6C5)
AC16-0010-01 Anti-GAPDH Antibody (AMCA) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6C5)
AC16-0010-02 Anti-GAPDH Antibody (AP) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6C5)
AC16-0010-03 Anti-GAPDH Antibody (APC) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6C5)
AC16-0010-04 Anti-GAPDH Antibody (APC-Cy5.5) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6C5)
AC16-0010-05 Anti-GAPDH Antibody (APC-Cy7) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6C5)
AC16-0010-06 Anti-GAPDH Antibody (Avidin) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6C5)
AC16-0010-07 Anti-GAPDH Antibody (Biotin) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6C5)
AC16-0010-08 Anti-GAPDH Antibody (BPE) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6C5)
AC16-0010-09 Anti-GAPDH Antibody (Cy3) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6C5)
AC16-0010-10 Anti-GAPDH Antibody (Cy5) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6C5)
AC16-0010-11 Anti-GAPDH Antibody (Cy5.5) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (6C5)