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Cancer Suseptibility

Cancer is a category of disease that encompasses many different individual ailments. When a cell’s normal replication and cell cycle processes go awry, cells can grow uncontrollably. This uncontrolled growth of abnormal cells in the body is called cancer or carcinoma. These growths are malignant- meaning that they will become progressively worse and can ultimately lead to death of the organism. Cancers are composed of invasive and metastatic cells. Carcinomas can involve any tissues, organ systems, and even the blood. The malignant tumors essentially invade nearby tissues and have the capability to spread to nearby or even distal parts of the body through the bloodstream or lymphatic system. What causes cancer is as widespread as the types of different cancers. Cancer susceptibility is one’s tendency to be pre-disposed to having cancer. Chromosomal, or DNA, instability is a common feature in most forms of cancer. Mutations in genes or genetic markers can, at times, be great predictors of whether cancer will occur. Those with family members that have had cancer are often times at a greater rate of getting cancer themselves. Other risk factors include age, environmental choices, and gender/race.

Anti-MLH3 antibody binds against target MLH3 antigen. MLH3 is involved in repair of mismatched DNA. MLH3 is localized in the cell nucleus and is ubiquitously expressed in all bodily cells. Defects in MLH3 are a cause of colorectal cancer. Colorectal cancer, or colon cancer, is a cancer of the large intestine or rectum. Anti-PMS1 antibody binds against the target PMS1 antigen. PMSI is localized in the nucleus and is involved in the repair of mismatches in DNA. Defects in PMS1 are the cause of hereditary non-polyposis colorectal cancer type 3. Hereditary non-polyposis colorectal cancer type 3 is also called Lynch syndrome and is a form of inherited colon cancer.


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