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Cancer Drug Resistance

Although there are many different types of treatments for cancer, and many of them are quite useful and sophisticated, there is no 100% successful cure for any form of cancer. Part of this is due to the resistance formed by cancer cells against certain types of cancer drugs, like chemotherapy agents. This resistance can result from a variety of factors including variations within patients and differences between the actual cancers or tumors. The mechanisms of cancer drug resistance can be quite complicated. Involved is a cancer cell’s ability to remove chemotherapeutic agents from itself and the cancer cell’s refusal to respond to directed apoptosis signals by cancer drugs. Also, cancer stem cells have proven to be especially resistant to therapeutics. Host factors that contribute to cancer drug resistance include poor absorption of the drug, rapid metabolism of the drug, or drug excretion which results in low serum levels of the chemotherapy agent. Also, chemotherapy can have some detrimental side effects that some patients (specifically in elderly or infirmed patients) are unable to tolerate. In addition, chemo agents can be large in size or tumors can be elusive, and thus drug delivery becomes a problem. Each type of cancer and each type of cancer cells, even among the same type of cancer, are truly unique in composition and response to chemo agents. This uniqueness can arise from the genetic make-up of the affected individual or the tissue of origin. As such, each cancer cell (even within the same individual, or tumor) can respond differently to anti-cancer drugs. Even the normal cells within a person can be responsible for highjacking anti-cancer agents and degrading them before they get a chance to take action against the cancer.

Anti-MRP1 antibody binds against the target multidrug resistance protein 1. MRP1 is localized on the cell membrane and expressed in lung, testis, and peripheral blood mononuclear cells. MRP1 is a mediator of organic anion and drug export out of the cytoplasm and plays an integral role in cancer drug resistance. Anti-MRP4 antibody binds against the target MRP4 or multi-specific organic anion transporter B. MRP4 is localized on the cell membrane and expressed in the prostate and to a very small extent in the liver. MRP4 is thought to be an organic anion pump that helps to detoxify cells and also remove chemotherapy agents and thus play a role in cancer drug resistance.

 
Product Number Title Applications Host Clonality
AC21-2672 Anti-MRP8 Antibody ELISA, WB Goat Polyclonal
AC21-2843 Anti-MRP3 Antibody ELISA Goat Polyclonal
AC21-2846 Anti-MRP4 Antibody ELISA Goat Polyclonal
AC21-0614-01 Anti-MRP4 Antibody (AMCA) ELISA, WB, IHC, ICC Goat Polyclonal
AC21-0614-02 Anti-MRP4 Antibody (AP) ELISA, WB, IHC, ICC Goat Polyclonal
AC21-0614-03 Anti-MRP4 Antibody (APC) ELISA, WB, IHC, ICC Goat Polyclonal
AC21-0614-04 Anti-MRP4 Antibody (APC-Cy5.5) ELISA, WB, IHC, ICC Goat Polyclonal
AC21-0614-05 Anti-MRP4 Antibody (APC-Cy7) ELISA, WB, IHC, ICC Goat Polyclonal
AC21-0614-06 Anti-MRP4 Antibody (Avidin) ELISA, WB, IHC, ICC Goat Polyclonal
AC21-0614-07 Anti-MRP4 Antibody (Biotin) ELISA, WB, IHC, ICC Goat Polyclonal
AC21-0614-08 Anti-MRP4 Antibody (BPE) ELISA, WB, IHC, ICC Goat Polyclonal
AC21-0614-09 Anti-MRP4 Antibody (Cy3) ELISA, WB, IHC, ICC Goat Polyclonal