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Calcium Signaling

The nervous system is an organ system which contains a grid of specialized neuronal cells called neurons. The human nervous system consists of two major parts called the central nervous system and the peripheral nervous system. The central nervous system in vertebrates contains the brain, spinal cord, and eyes. The peripheral nervous system contains sensory neurons which connect peripheral body parts to each other and to the central nervous system. Neurons, whether in the peripheral or central nervous system, function by transmitting chemical and/or electrical signals between each other, typically across a space called a synapse. Neurotransmission refers to the process of signaling between cells or other molecules in the nervous system that occurs when a surface cell receptor is activated by a molecule, such as an antibody, creating a response. The resulting action then mediates a reaction within the cell through a second messenger which elicits the physiological response. Along the way, amplification signals can be used to further facilitate the signal. Calcium signaling is a very important aspect of neurotransmission and many cellular functions. Many cells use both extracellular and intracellular sources of calcium. The movement of calcium from outside the cell to the inside of the cell changes the membrane potential, depolarizing it. This movement occurs through ion channels on the surface of cells. Once inside the cell, calcium can be used as a second messenger signaling molecule. Calcium signaling is implicated in numerous tasks including muscle contraction, neurotransmission, and cardiac myocyte signaling.

Anti-Polycystin 1 antibody binds against the target polycystin 1. Polycystin 1 is an ion-channel regulator and is involved in protein to protein and protein to carbohydrate adhesion. Defects in PKD1 are the cause of polycystic kidney disease. Polycystic kidney disease is a genetic disorder in which affected individuals may form cysts on their kidneys, causing them to grow in size. Typically, PKD follows a dominant inheritance, but there is also a recessive form caused by mutations in polycystin 1. The autosomal recessive form is much more rare, and typically appears in infancy. Anti-NIR1 antibody binds against the target NIR1. NIR1 is localized in the endomembrane system and detected in the brain, spleen, and ovary. NIR1 catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes and binds calcium ions. Defects in NIR1 are the cause of cone-rod dystrophy. Cone-rod dystrophy is a progressive, inherited disease that causes deterioration of the cones and rods in the eye. This deterioration typically results in loss of color vision, visual acuity, peripheral vision, and night vision. CRDs are characterized by pigment deposits on the retina that are visible upon examination and can lead to complete loss of vision.

Product Number Title Applications Host Clonality
AC21-2664 Anti-DCHS1 Antibody ELISA Goat Polyclonal
AC21-2672 Anti-MRP8 Antibody ELISA, WB Goat Polyclonal
AC21-2700 Anti-Synaptotagmin VI Antibody ELISA Goat Polyclonal
AC21-2703 Anti-Synaptotagmin V Antibody ELISA, WB Goat Polyclonal
AC21-2748 Anti-Calbindin Antibody ELISA, WB Goat Polyclonal
AC21-2875 Anti-SLC8A3 Antibody ELISA Goat Polyclonal
AC21-2876 Anti-SLC8A3 Antibody ELISA Goat Polyclonal
AC21-2888 Anti-TRPC6 Antibody ELISA Goat Polyclonal
AC21-2924 Anti-Calpain 1 Antibody ELISA, WB Goat Polyclonal
AC21-2925 Anti-Calpain 1 Antibody ELISA, WB Goat Polyclonal
AC21-0054-01 Anti-Tensin 1 Antibody (AMCA) ELISA, WB, IHC Goat Polyclonal
AC21-0054-02 Anti-Tensin 1 Antibody (AP) ELISA, WB, IHC Goat Polyclonal