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Bcl Related

The Bcl related apoptotic pathways are involved in pre-programmed cell death. Bcl stands for B cell lymphoma and is the founding protein of the Bcl related apoptosis regulator proteins encoded by the BCL related genes. There are many Bcl related groups including the bcl2 pathway and the bcl-xL, Bcl-w, Bcl-xs, and Mcl-1 proteins. Apoptosis is required in order to remove infected, damaged, or old cells so that they can be replaced by new, fresh substitutes. Bcl related molecules suppress apoptosis in response to a large range of stimuli encountered during tumor development and DNA damage. Furthermore, the Bcl-2 pathway is encoded by the BAK1 gene. The BAK1 gene exists in many mammals for which we know the genomic data. Several BAK1 variants exist of which may change the function and structure of the Bcl 2 pathway essentially leading to many types of cancer. The Bcl-2 apoptotic pathway can coordinate with the p53 tumor suppressor and inactivate genes like BAK which promotes the growth of solid tumors in epithelial tissues as well as resistance to treatment with chemotherapy. The Bcl-xL, or B cell lymphoma extra large, is a transmembrane molecule in the mitochondria. It works by preventing the release of cytochrome C. Essentially, the more Bcl-xL in the cell, the more likely the cell will survive. Bcl-w, or bcl-2-like protein 2, is a protein encoded for by the BCL2L2 gene and is another bcl-related pro-survival (anti-apoptotic) molecule.

Anti-Bag3 antibody binds against the target Bag3. Bag3 inhibits the activity of certain apoptotic properties by promoting release of substrates. Its anti-apoptotic activity can facilitate the growth of certain cancers. Defects in BAG 3 cause myofibrillar myopathy. Myofibrillar myopathy is a genetic neuromuscular disorder characterized by structural changes in the intracellular agglomeration of filament proteins like desmin. Affected individuals suffer from muscle weakness associated with cardiomyopathy, respiratory insufficiency, and a rigid spine. Anti-Bcl-2 antibody binds against bcl-2. Bcl-2, as stated above, suppresses apoptosis in many different cells and tissues. Bcl2 is located on the mitochontrion outer membrane, the nuclear membrane, and the endoplasmic reticulum membrane. Defects in BCL2 are thought to cause lymphatic leukemia, non-hodgkin lymphoma, and other types of cancers.

 
Product Number Title Applications Host Clonality
AC21-2839 Anti-BCL2L15 Antibody ELISA Goat Polyclonal
AC21-2978 Anti-Bcl2A1 Antibody ELISA, WB Goat Polyclonal
AC21-0070-01 Anti-BAG2 Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0070-02 Anti-BAG2 Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0070-03 Anti-BAG2 Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0070-04 Anti-BAG2 Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal
AC21-0070-05 Anti-BAG2 Antibody (APC-Cy7) ELISA, WB Goat Polyclonal
AC21-0070-06 Anti-BAG2 Antibody (Avidin) ELISA, WB Goat Polyclonal
AC21-0070-07 Anti-BAG2 Antibody (Biotin) ELISA, WB Goat Polyclonal
AC21-0070-08 Anti-BAG2 Antibody (BPE) ELISA, WB Goat Polyclonal
AC21-0070-09 Anti-BAG2 Antibody (Cy3) ELISA, WB Goat Polyclonal
AC21-0070-10 Anti-BAG2 Antibody (Cy5) ELISA, WB Goat Polyclonal