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Axon Markers

Neurons are specialized cells of the nervous system designed to transmit chemical and electrical signals throughout the body. A biological marker is an indicator of a biological state. Often times it may be difficult to take biopsy or living tissue sample for medical diagnostics or scientific research purposes. Neuronal markers make it easier to look into the nervous system. Neuronal markers are present in the brain and peripheral nervous system and are indicative of certain neuronal diseases, statuses, or conditions. Neuronal markers are typically very effective diagnostic or prognostic tools in the treatment of sickness. These biomarkers can also be used to identify neural cells or detect expression details of certain types of molecules. Neuron marker antibodies sold by Abcore Inc. can be categorized into axon markers, dendrite markers, growth cone markers, soma markers, and synapse markers.

Anti-Kinesin 5A antibody binds against the target kinesin 5A. KIF5A is localized in the perinuclear region of the cytoplasm and in the cytoskeleton. Kinesin 5A is a microtubule dependent moto required for slow axonal transport of neurofilament proteins. Defects in KIF5A are the cause of spastic paraplegia autosomal dominant type 10. Hereditary spastic paraplegia is a disease characterized by progressive stiffness and contraction (spasticity) of the lower limbs. Affected individuals experience progressive difficulty walking (trouble with balance and stumbling) that starts between 20 and 40 years of age. As hereditary spastic paraplegia progresses, individuals experience urinary urgency, hyperactive reflexes, muscle spasms, and congenital foot defects. There are no treatments available to cure the disorder, but there are medications that can help decrease symptom severity and help reduce spasticity. Therapy is centered on maintaining flexibility, strength, and range of motion. Supplemental devices are also used to help with movement as well as communication is patients where the disorder has progressed. Anti-myelin protein zero antibody binds against the target myelin protein zero. Myelin protein zero is localized on membranes and found only in the peripheral nervous system Schwann cells. The protein is implicated in creating the extracellular membrane face which can guide the wrapping process of adjacent lamellae. Defects in myelin protein zero are the ccause of Charcot-Marie-Tooth disease, Dejerine-Sottas syndrome, hypomyelination neuropathy, and Roussy-Levy syndrome. Charcot-Marie-Tooth disease is a group of genetic disorders that affects peripheral nerves. People affected with Charcot-Marie-Tooth disease experience a loss of touch sensation in the peripheral limbs and neuropathic pain. Dejerine-Sottas syndrome is a hereditary motor disease characterized by moderate to severe lower and upper extremity weakness. Onset occurs in infancy and early childhood with typically slow progression until the teenage years where the disease than progresses rapidly. Hypomyelination neuropathy is a neurological disorder present at birth characterized by respiratory difficulty, muscle weakness, and loss of coordination. Roussy-Levy syndrome is a neuromuscular disorder characterized by poor judgement of movement, absence of reflexes, and muscle atrophy.

 
Product Number Title Applications Host Clonality
AC21-0205-01 Anti-Kinesin 5A Antibody (AMCA) ELISA Goat Polyclonal
AC21-0205-02 Anti-Kinesin 5A Antibody (AP) ELISA Goat Polyclonal
AC21-0205-03 Anti-Kinesin 5A Antibody (APC) ELISA Goat Polyclonal
AC21-0205-04 Anti-Kinesin 5A Antibody (APC-Cy5.5) ELISA Goat Polyclonal
AC21-0205-05 Anti-Kinesin 5A Antibody (APC-Cy7) ELISA Goat Polyclonal
AC21-0205-06 Anti-Kinesin 5A Antibody (Avidin) ELISA Goat Polyclonal
AC21-0205-07 Anti-Kinesin 5A Antibody (Biotin) ELISA Goat Polyclonal
AC21-0205-08 Anti-Kinesin 5A Antibody (BPE) ELISA Goat Polyclonal
AC21-0205-09 Anti-Kinesin 5A Antibody (Cy3) ELISA Goat Polyclonal
AC21-0205-10 Anti-Kinesin 5A Antibody (Cy5) ELISA Goat Polyclonal
AC21-0205-11 Anti-Kinesin 5A Antibody (Cy5.5) ELISA Goat Polyclonal
AC21-0205-12 Anti-Kinesin 5A Antibody (FITC) ELISA Goat Polyclonal