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Apoptosis Receptors

Apoptosis is the process by which cells die a pre-programmed cell death or PCD. The process is facilitated by processes within the cell using certain biochemicals that lead to changes in cell morphology and eventually leads to the cell dying. This is a natural process in the cell cycle and is necessary to maintain proper alignments of organ and organelle structure. Defects in the apoptosis of cells can lead to diseases such as cancer. Each cell must die in order to make room for fresh replacements. Apoptosis is essentially induction of cell suicide. Apoptosis can be triggered by internal or external signals. Some of the identifying events of apoptosis include DNA fragmentation, shrinkage, and releasing of energy stores. Apoptosis receptor antibodies are involved in apoptosis and can facilitate, block, or slow down the process of pre-programmed cell death. Apoptosis receptors, or death receptors, possess cytoplasmic death domains and can be triggered by apoptosis receptor antibodies as well as other ligands.

Anti-Fas Ligand antibody is a cytokine that binds to a receptor that communicates the apoptotic signal into cells. This can halt the message and postpone T-cell mediated apoptosis. Defects in this protein result in autoimmune syndromes like autoimmune lymphoproliferative syndrome type 1B. Autoimmune lymphoproliferative syndromes can be inherited by a dominant or recessive fashion. Symptoms include haematological autoimmunity, enlarged lymph nodes and spleen, decreased Fas death receptor function, and peripheral blood expansion of T cells. Individuals with autoimmune lymphoproliferative syndromes are at increased risk of developing lymphoma. The anti-hemopexin antibody binds to heme in blood and transports it to the liver for it to be broken down. After the breakdown, the iron is recovered and used in other applications and the free hemopexin is returned into general circulation to start the process over again.

 
Product Number Title Applications Host Clonality
AC16-0042 Anti-EDG1 Antibody WB, IHC(F), IHC(P) Mouse Monoclonal (2B9)
AC16-0048 Anti-TNF Receptor I Antibody ELISA, WB, IHC(P), FC Rabbit Polyclonal
AC16-0059 Anti-TNF Receptor I Antibody ELISA, IHC(F), ICC, IF, FC Mouse Monoclonal (htr9)
AC16-0060 Anti-TNF Receptor I Antibody WB, IHC(F), IHC(P), ICC, IF, FC Mouse Monoclonal (utr1)
AC16-0042-01 Anti-EDG1 Antibody (AMCA) WB, IHC(F), IHC(P) Mouse Monoclonal (2B9)
AC16-0042-02 Anti-EDG1 Antibody (AP) WB, IHC(F), IHC(P) Mouse Monoclonal (2B9)
AC16-0042-03 Anti-EDG1 Antibody (APC) WB, IHC(F), IHC(P) Mouse Monoclonal (2B9)
AC16-0042-04 Anti-EDG1 Antibody (APC-Cy5.5) WB, IHC(F), IHC(P) Mouse Monoclonal (2B9)
AC16-0042-05 Anti-EDG1 Antibody (APC-Cy7) WB, IHC(F), IHC(P) Mouse Monoclonal (2B9)
AC16-0042-06 Anti-EDG1 Antibody (Avidin) WB, IHC(F), IHC(P) Mouse Monoclonal (2B9)
AC16-0042-07 Anti-EDG1 Antibody (Biotin) WB, IHC(F), IHC(P) Mouse Monoclonal (2B9)
AC16-0042-08 Anti-EDG1 Antibody (BPE) WB, IHC(F), IHC(P) Mouse Monoclonal (2B9)
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