Alexa Fluor® antibodies encompass a family of bright, photostable fluorescently died or conjugated antibodies. Alexa Fluor® dyes are from molecular probes and Alexa Fluor® antibodies are useful in many avenues of biological and chemical research. Abcore offers a variety of Alexa Fluor® tagged fluorescent antibodies including Alexa Fluor® 488, Alexa Fluor® 647, and Alexa Fluor® 700. The number succeeding Alexa Fluor® corresponds to the category of die characterized by the color, absorption, emittance, and molar mass. Alexa Fluor® 488 is a cyan-green colored tag. Alexa Fluor® 647 is a red color die as is Alexa Fluor® 700. Molecular probes like Alexa Fluor® conjugates are useful in labeling and detecting specific properties of molecules and structures. Molecular probes are attached to other molecules and can be an atom or a molecule. In the case of Alexa Fluor® molecular probes, the attached molecule is a fluorescent die. This die is excitable and emits a spectrum of visible light. Alexa Fluor® dyes are made by sulfonating coumarine, rhodamine, fluorescein, and cyanine. Alexa Fluor® dyes are negatively charged and hydrophilic. In comparison to other common dyes, Alexa Fluor® conjugated antibodies are more stable, less pH sensitive, and brighter.

CD3 antibody (Alexa Fluor®700 ) has been used in research regarding B cell lymphoma as well as brain tumors. The CD3 complex is a mediator of signal transduction localized on the cell membrane. Defects in CD3 and anti- CD3 antibody can cause several severe immunodeficiency disorders among a specific group of ailments characterized by low antibody levels and specific immunities due to poor T- cell development. Anti-NTAL antibody (Alexa Fluor®488) binds against the NTAL target. NTAL is expressed in the cell membrane and lipid rafts in cells of the spleen, peripheral blood lymphocytes, germinal centers of lymph nodes, placenta, lung, pancreas, small intestine, and B-cells. NTAL protein is involved with the high affinity immunoglobulin epsilon receptor FCER1. It is thought to be involved in B-cell antigen receptor mediated signaling in B-cells and FCGR1 mediated signaling in myeloid cells. Defects or deletions in the gene encoding for NTAL can be the cause of Williams-Beuren syndrome (WBS). William’s syndrome is a rare genetic condition that is characterized by cardiovascular disease, developmental delays, learning disabilities, unique facial features, and highly social personalities.