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Alexa Fluor® 647 Antibodies

Alexa Fluor®647 antibodies are conjugated to Alexa Fluor® 647. Alexa Fluor® 647 is a molecular probe exhibiting a red color which absorbs light at 650 nm. Alexa Fluor® 647 emits light at 665 nm, and has a molar mass of approximately 1300 g/mol. Alexa Fluor® 647 has a quantum yield of .33. Molecular probes like Alexa Fluor® 647 conjugates are useful in labeling and detecting specific properties of molecules and structures. Molecular probes are attached to other molecules and can be an atom or a molecule. In the case of Alexa Fluor® 647 molecular probes, the attached molecule is a fluorescent die. This die is excitable and emits a spectrum of visible light. Alexa Fluor® 647 dyes are made by sulfonating coumarine, rhodamine, fluorescein, and cyanine. Alexa Fluor® dyes are negatively charged and hydrophilic. In comparison to other common dyes, Alexa Fluor® 647 conjugated antibodies are more stable, less pH sensitive, and brighter.

Anti-CD105 antibody (Alexa Fluor®647) binds against a major glycoprotein of the vascular endothelium. It is localized on the membrane and expressed in endoglin restricted to endothelial cells in all tissues except bone marrow. CD105/ENG is thought to play an integral role in the binding of endothelial cells to integrins and/or RGD receptors. Defects in ENG/CD105 are the cause of Osler-Rendu-Weber Syndrome 1. Osler-Rendu-Weber Syndrome 1 is a genetic disorder in which affected individuals develop arteriovenous malformations (abnormal blood vessels) in many areas in the body. The disease is characterized by frequent nosebleeds, gastrointestinal tract bleeding, seizures, strokes, shortness of breath, and the presence of large birthmarks called “port-wine stain”. Anti-CD9 antibody (Alexa Fluor®647) is expressed in the membrane of cells located in a variety of hematopoietic and epithelial cells. Anti-CD9 antibody (Alexa Fluor®647) binds against CD9 target which is involved in platelet activation and aggregation. CD9 regulates paranodal junction formation and is also involved in cell adhesion, cell motility, and tumor metastasis. CD9 is required for sperm-egg fusion during reproduction.

Product Number Title Applications Host Clonality
A6-208 Anti-CD9 Antibody (Alexa Fluor® 647) WB, IHC(P), FC, FUNC Mouse Monoclonal (MEM-61)
A6-315 Anti-Mannose 6 Phosphate Receptor Antibody (Alexa Fluor® 647) WB, FC Mouse Monoclonal (MEM-238)
A6-364 Anti-CD1a Antibody (Alexa Fluor® 647) IHC(F), FC Mouse Monoclonal (HI149)
A6-455 Anti-CD30 Antibody (Alexa Fluor® 647) IHC(P), FC Mouse Monoclonal (MEM-268)
A6-458 Anti-Mouse IgG2a Isotype Control Antibody (Alexa Fluor® 647) FC Mouse Monoclonal (PPV-04)
A6-459 Anti-Mouse IgG3 Isotype Control Antibody (Alexa Fluor® 647) FC Mouse Monoclonal (PPV-07)
A6-531 Anti-CD86 Antibody (Alexa Fluor® 647) WB, IHC(F), IP, FC, FUNC Mouse Monoclonal (BU63)
A6-552 Anti-CD69 Antibody (Alexa Fluor® 647) IHC(F), FC, FUNC Mouse Monoclonal (FN50)
A6-601 Anti-FoxP3 Antibody (Alexa Fluor® 647) WB, FC Mouse Monoclonal (3G3)
A6-632 Anti-Mouse IgG1 Isotype Control Antibody (Alexa Fluor® 647) WB, IHC(F), IHC(P), IP, FC Mouse Monoclonal (MOPC-21)
A6-269 Anti-Lck Antibody (Alexa Fluor® 647) WB, ICC, IP, FC Mouse Monoclonal (LCK-01)
A6-314 Anti-CD177 Antibody (Alexa Fluor® 647) WB, IP, FC Mouse Monoclonal (MEM-166)