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Alexa Fluor® 488 Antibodies

Alexa Fluor®488 antibodies are conjugated to Alexa Fluor® 488. Alexa Fluor® 488 is a molecular probe exhibiting a cyan-green color which absorbs light at 495 nm. Alexa Fluor® 488 emits light at 519 nm, and has a molar mass of 643 g/mol. Alexa Fluor® 488 has a quantum yield of .92. Molecular probes like Alexa Fluor® 488 conjugates are useful in labeling and detecting specific properties of molecules and structures. Molecular probes are attached to other molecules and can be an atom or a molecule. In the case of Alexa Fluor® 488 molecular probes, the attached molecule is a fluorescent die. This die is excitable and emits a spectrum of visible light. Alexa Fluor® 488 dyes are made by sulfonating coumarine, rhodamine, fluorescein, and cyanine. Alexa Fluor® 488 dyes are negatively charged and hydrophilic. In comparison to other common dyes, Alexa Fluor® 488 conjugated antibodies are more stable, less pH sensitive, and brighter.

Anti-NTAL antibody (Alexa Fluor®488) binds against the NTAL target. NTAL is expressed in the cell membrane and lipid rafts in cells of the spleen, peripheral blood lymphocytes, germinal centers of lymph nodes, placenta, lung, pancreas, small intestine, and B-cells. NTAL protein is involved with the high affinity immunoglobulin epsilon receptor FCER1. It is thought to be involved in B-cell antigen receptor mediated signaling in B-cells and FCGR1 mediated signaling in myeloid cells. Defects or deletions in the gene encoding for NTAL can be the cause of Williams-Beuren syndrome (WBS). William’s syndrome is a rare genetic condition that is characterized by cardiovascular disease, developmental delays, learning disabilities, unique facial features, and highly social personalities. Anti-CD105 antibody (Alexa Fluor®488) binds against a major glycoprotein of the vascular endothelium. It is localized on the membrane and expressed in endoglin restricted to endothelial cells in all tissues except bone marrow. CD105/ENG is thought to play an integral role in the binding of endothelial cells to integrins and/or RGD receptors. Defects in ENG/CD105 are the cause of Osler-Rendu-Weber Syndrome 1. Osler-Rendu-Weber Syndrome 1 is a genetic disorder in which affected individuals develop arteriovenous malformations (abnormal blood vessels) in many areas in the body. The disease is characterized by frequent nosebleeds, gastrointestinal tract bleeding, seizures, strokes, shortness of breath, and the presence of large birthmarks called “port-wine stain”.

 
Product Number Title Applications Host Clonality
A4-106 Anti-Cytokeratin 18 Antibody (Alexa Fluor® 488) ELISA, WB, IHC(P), ICC, IP, FC Mouse Monoclonal (C-04)
A4-431 Anti-HLA G Antibody (Alexa Fluor® 488) ELISA, WB, IHC(F), IHC(P), ICC, FC Mouse Monoclonal (5A6G7)
A4-437 Anti-HLA G Antibody (Alexa Fluor® 488) ELISA, IHC, FC, FUNC Mouse Monoclonal (87G)
A4-458 Anti-Mouse IgG2a Isotype Control Antibody (Alexa Fluor® 488) FC Mouse Monoclonal (PPV-04)
A4-459 Anti-Mouse IgG3 Isotype Control Antibody (Alexa Fluor® 488) FC Mouse Monoclonal (PPV-07)
A4-465 Anti-gamma Tubulin Antibody (Alexa Fluor® 488) WB, ICC Mouse Monoclonal (TU-30)
A4-474 Anti-HLA DR Antibody (Alexa Fluor® 488) WB, IP, FC Mouse Monoclonal (MEM-12)
A4-539 Anti-PSMA Antibody (Alexa Fluor® 488) ICC, IP, FC Mouse Monoclonal (GCP-05)
A4-553 Anti-CD45 Antibody (Alexa Fluor® 488) WB, ICC, IP , FC Rat Monoclonal (EM-05)
A4-556 Anti-HLA A2 Antibody (Alexa Fluor® 488) IP, FC Mouse Monoclonal (BB7.2)
A4-579 Anti-CD8 alpha Antibody (Alexa Fluor® 488) IHC(F), IHC(P), IP, FC, FUNC Rat Monoclonal (53-6.7)
A4-599 Anti-CD3 Antibody (Alexa Fluor® 488) WB, IHC(F), ICC, IP, FC Mouse Monoclonal (APA1/1)