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ADP-Ribosylation

Chromatin is the structure formed between DNA and proteins assembled in the cell's nucleus. The nucleosome, the basic unit of chromatin, is highly condensed making the individual genetic material or genes on the DNA hidden or inaccessible by certain biological molecules. The DNA is wound around histone proteins. Chromatin modification involves enzymes that affect DNA transcription. Chromatin modifying enzymes essentially work to make the condensed chromatin accessible for transcription factors, DNA replication, recombination, and repair. There are many different surfaces to nucleosomes which provide many different binding sites for chromatin modifying enzymes. There are at least eight different classes of modifiers which have been characterized based on site and mechanism of action. These chromatin modifying enzymes have the potential to influence many fundamental biological processes of which some may be epigenetically inherited. ADP-ribosylation is the addition of ADP-ribose to a protein byway of certain modification enzymes called ADP-ribosyltransferases. ADP-ribosyltransferases transfer the ADP-ribose group by modifying amino acid residues. The addition is implicated in the control of many cellular processes including DNA repair and apoptosis. ADP-ribosylation is reversible and the added ADP sugar can be removed by enzymes like ADP-ribosyl hydrolases.

Anti-PARP2 antibody binds against the target poly (ADP ribose) polymerase 2. PARP2 is localized in the cell nucleus and widely expressed in actively dividing tissues. PARP2 is expressed in the highest amount in the brain, heart, pancreas, skeletal muscle, and testis. PARP2 is involved in DNA base excision repair. It catalyzes ADP-ribosylation in a small number of acceptor proteins. Anti-PSD3 antibody binds against the target PSD3. PSD3 is localized in the cell junction, synapse, and the postsynaptic cell membrane. PSD3 is a guanine nucleotide exchange factor that potentially suppresses tumors in ovarian cancer. Ovarian cancer is a cancer that starts in the female reproductive system egg producing organ. Ovarian cancer is a relatively common cancer among women and can result in death. Symptoms of ovarian cancer include bloated abdomen, difficulty eating, and indigestion.

 
Product Number Title Applications Host Clonality
AC21-0448-01 Anti-PSD3 Antibody (AMCA) ELISA Goat Polyclonal
AC21-0448-02 Anti-PSD3 Antibody (AP) ELISA Goat Polyclonal
AC21-0448-03 Anti-PSD3 Antibody (APC) ELISA Goat Polyclonal
AC21-0448-04 Anti-PSD3 Antibody (APC-Cy5.5) ELISA Goat Polyclonal
AC21-0448-05 Anti-PSD3 Antibody (APC-Cy7) ELISA Goat Polyclonal
AC21-0448-06 Anti-PSD3 Antibody (Avidin) ELISA Goat Polyclonal
AC21-0448-07 Anti-PSD3 Antibody (Biotin) ELISA Goat Polyclonal
AC21-0448-08 Anti-PSD3 Antibody (BPE) ELISA Goat Polyclonal
AC21-0448-09 Anti-PSD3 Antibody (Cy3) ELISA Goat Polyclonal
AC21-0448-10 Anti-PSD3 Antibody (Cy5) ELISA Goat Polyclonal
AC21-0448-11 Anti-PSD3 Antibody (Cy5.5) ELISA Goat Polyclonal
AC21-0448-12 Anti-PSD3 Antibody (FITC) ELISA Goat Polyclonal