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Adipose Related

Adipose is another word for fat. Lipid is a general term for a group of molecules including fats, waxes, phospholipids, and glycerides. Adipose tissue is mainly responsible for energy storage, structural stability of cells, and signaling between cells. Lipids are hydrophobic molecules which mean they are not water soluble, are non-polar, and repel water. They are, however, soluble in organic solvents such as acetone and ether as well as in other lipids or fats. Although there are different types of lipids, they are mostly composed of carbon backbones or hydrocarbon chains with extra components depending on what type of lipid they are. Fats are composed of 3 fatty acids and a glycerol molecule. Phospholipids are composed of 2 fatty acids, a glycerol, and a phosphate. Steroids and waxes are ring like structures with a carbon skeleton. Lipid antibodies can react against proteins or molecules that bind to adipose type particles. There are relatively few antibodies that have the affinity to bind against lipids. However, there is more and more evidence for the presence of these adipose related antibodies in individuals with HIV infections and autoimmune brain inflammation such as multiple sclerosis.

Anti-abhd5 antibody binds against abhydrolase domain containing protein 5. Abhd5 is localized in the cytoplasm and lipid droplet and expressed in a variety of tissues including lymphocytes, liver, skeletal muscle, and brain. Abhydrolase domain containing protein 5 is a lysophosphatidic acid acyltransferase that functions in phosphatidic acid biosynthesis. Abhd4 regulates triacylglycerol storage and is involved in keratinocyte differentiation. Defects in ABHD5 are the cause of Chanarin-Dorfman syndrome. Chanarin-Dorfman syndrome is an inherited condition that causes the body to store fats in an abnormal fashion. Affected individuals have difficulty breaking down triglycerides and thus they accumulate in organs and tissues. Anti-lipin 2 antibody binds against the target protein lipin 2 and is encoded by the gene LPIN2. Lipin 2 plays an integral role in controlling fatty acid metabolism. Lipin 2 is localized in the nucleus, cytoplasm, and the endoplasmic reticulum membrane. The protein is expressed in the liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon. Defects in LPIN2 are the cause of Majeed syndrome. Majeed syndrome is a genetic skin disorder characterized by inflammatory dermatosis, congenital dyserythropoietic anaemia, and chronic recurrent multifocal osteomyelitis.

 
Product Number Title Applications Host Clonality
AC16-0062 Anti-ADFP Antibody WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (AP125)
AC16-0062-01 Anti-ADFP Antibody (AMCA) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (AP125)
AC16-0062-02 Anti-ADFP Antibody (AP) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (AP125)
AC16-0062-03 Anti-ADFP Antibody (APC) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (AP125)
AC16-0062-04 Anti-ADFP Antibody (APC-Cy5.5) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (AP125)
AC16-0062-05 Anti-ADFP Antibody (APC-Cy7) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (AP125)
AC16-0062-06 Anti-ADFP Antibody (Avidin) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (AP125)
AC16-0062-07 Anti-ADFP Antibody (Biotin) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (AP125)
AC16-0062-08 Anti-ADFP Antibody (BPE) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (AP125)
AC16-0062-09 Anti-ADFP Antibody (Cy3) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (AP125)
AC16-0062-10 Anti-ADFP Antibody (Cy5) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (AP125)
AC16-0062-11 Anti-ADFP Antibody (Cy5.5) WB, IHC(F), IHC(P), ICC, IF, IP, FC Mouse Monoclonal (AP125)