Questions? Feedback? powered by Olark live chat software

Adapter Proteins

Adapter proteins are proteins that act as connecting molecules. They are essential in intermolecular interactions and play numerous essential roles in signal transduction by mediating specific protein-protein interactions that drive the formation of protein complexes. Signal transduction refers to the process of signaling between cells or other molecules in the cellular environment that occurs when a surface cell receptor is activated by a molecule, such as an adapter protein antibody, creating a response. Adapter proteins contain a number of different protein binding cohorts which together facilitate the creation of larger signaling complexes. There are many categories of adapter proteins which include T-cell receptor signaling adaptor proteins, B-cell adapter proteins, toll-like receptor proteins, neuronal adapter proteins, and autophagic adapter proteins.

Anti-LNK antibody binds against lymphocyte adapter protein. LNK links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2, and phosphatidylinositol 3-kinase. Lymphocyte adapter protein is expressed in lymphoid cell lines. Genetic variations in LNK are associated with susceptibility to celiac disease and insulin-dependent diabetes. Celiac disease is an autoimmune disorder of the small intestine. When an individual ingests wheat gluten, the body reacts by damaging the villi in the small intestine which interferes with their ability to absorb nutrients. Diabetes is a disorder characterized by high levels of blood sugar and the body's inability to produce insulin. Anti-ARH antibody binds against the target ARH. ARH is localized in the cytoplasm and expressed in the kidney, liver, placenta, brain, heart, muscle, colon, spleen, intestine, lung, and leukocytes. ARH is an adapter protein that is required for efficient endocytosis of the LDL receptor in hepatocytes and lymphocytes. Defects in ARH are the cause of autosomal recessive hypercholesterolemia. Autosomal recessive hypercholesterolemia is a rare disorder that is caused by a complete loss of function of the ARH adapter protein. This protein is required for the uptake of LDL (the "bad" cholesterol). ARH is characterized by increased cholesterol levels in the blood, deposition of cholesterol in the skin and tendons, and premature coronary artery disease.

 
Product Number Title Applications Host Clonality
AC21-1347-01 Anti-14-3-3 Tau Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-2648 Anti-CCNDBP1 Antibody ELISA, WB Goat Polyclonal
AC21-2761 Anti-IRS4 Antibody ELISA, WB Goat Polyclonal
AC21-2800 Anti-APPL Antibody ELISA, WB Goat Polyclonal
AC21-2809 Anti-FYB Antibody ELISA, WB Goat Polyclonal
AC21-2812 Anti-GRB10 Antibody ELISA, WB Goat Polyclonal
AC21-2974 Anti-NPHS2 Antibody ELISA, WB Goat Polyclonal
AC21-0018-01 Anti-SOCS3 Antibody (AMCA) ELISA, WB Goat Polyclonal
AC21-0018-02 Anti-SOCS3 Antibody (AP) ELISA, WB Goat Polyclonal
AC21-0018-03 Anti-SOCS3 Antibody (APC) ELISA, WB Goat Polyclonal
AC21-0018-04 Anti-SOCS3 Antibody (APC-Cy5.5) ELISA, WB Goat Polyclonal
AC21-0018-05 Anti-SOCS3 Antibody (APC-Cy7) ELISA, WB Goat Polyclonal